Modular peptide recognition domains in eukaryotic signaling

被引：454

作者：

Kuriyan, J

Cowburn, D

机构：

[1] Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021

[2] Rockefeller University, New York, NY 10021

来源：

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE | 1997年 / 26卷

关键词：

SH2; SH3; Src homology; tyrosine kinase; PTB; PDZ;

D O I：

10.1146/annurev.biophys.26.1.259

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A characteristic feature of cellular signal transduction pathways in eukaryotes is the separation of catalysis from target recognition. Several modular domains that recognize short peptide sequences and target signaling proteins to these sequences have been identified. The structural bases of the specificities of recognition by SH2, SH3, and PTB domains have been elucidated by X-ray crystallography and NMR, and these results are reviewed here. In addition, the mechanism of cooperative interactions between these domains is discussed.

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页码：259 / 288

页数：30

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