The Eukaryotic Ribosome: Current Status and Challenges

被引：27

作者：

Dinman, Jonathan D. ^{[1
]}

机构：

[1] Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2009年 / 284卷 / 18期

基金：

美国国家卫生研究院;

关键词：

PROTEIN-SYNTHESIS; TRANSFER-RNA; TRANSLATION; SUBUNIT; GENE; IDENTIFICATION; RECONSTITUTION; CONFORMATION; PHENOTYPE; CANDIDATE;

D O I：

10.1074/jbc.R800074200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Despite having been identified first, their greater degree of complexity has resulted in our understanding of eukaryotic ribosomes lagging behind that of their bacterial and archaeal counterparts. A much more complicated biogenesis program results in ribosomes that are structurally, biochemically, and functionally more complex. However, recent advances in molecular genetics and structural biology are helping to reveal the intricacies of the eukaryotic ribosome and to address many longstanding questions regarding its many roles in the regulation of gene expression.

引用

页码：11761 / 11765

页数：5

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