Synthesis and bioactivities of novel bicyclic thiophenes and 4,5,6,7-tetrahydrothieno[2,3-c]pyridines as inhibitors of tumor necrosis factor-α (TNF-α) production

被引：23

作者：

Fujita, M ^{[1
]}

Seki, T ^{[1
]}

Ikeda, N ^{[1
]}

机构：

[1] Nikken Chem Co Ltd, Pharmaceut Res Labs, Saitama 3300835, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(02)00332-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We synthesized bicyclic thiophenes and 4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives, and evaluated for their ability to inhibit LPS-stimulated production of TNF-alpha. Several compounds revealed excellent in vivo activity. Furthermore, an effective compound was found in adjuvant-induced arthritic model (AIA) of rat. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1897 / 1900

页数：4

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