Fast, cheap and somewhat in control

被引:66
作者
Arkin, Adam P. [1 ]
Fletcher, Daniel A.
机构
[1] Univ Calif Berkeley, Dept Bioengn, Howard Hughes Med Inst, Berkeley, CA 94720 USA
[2] EO Lawrence Berkeley Natl Lab, Phys Biosci Div, Berkeley, CA 94720 USA
[3] Virtual Inst Microbial Stress & Survival, Albany, CA 94710 USA
[4] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA
关键词
D O I
10.1186/gb-2006-7-8-114
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Efforts to manipulate living organisms have raised the question of whether engineering principles of hierarchy, abstraction and design can be applied to biological systems. Here, we consider the practical challenges to controlling living organisms that must be surmounted, or at least managed, if synthetic biology and cellular bioengineering are to be productive.
引用
收藏
页数:6
相关论文
共 35 条
[11]   Experimental determination and system level analysis of essential genes in Escherichia coli MG1655 [J].
Gerdes, SY ;
Scholle, MD ;
Campbell, JW ;
Balázsi, G ;
Ravasz, E ;
Daugherty, MD ;
Somera, AL ;
Kyrpides, NC ;
Anderson, I ;
Gelfand, MS ;
Bhattacharya, A ;
Kapatral, V ;
D'Souza, M ;
Baev, MV ;
Grechkin, Y ;
Mseeh, F ;
Fonstein, MY ;
Overbeek, R ;
Barabási, AL ;
Oltvai, ZN ;
Osterman, AL .
JOURNAL OF BACTERIOLOGY, 2003, 185 (19) :5673-5684
[12]   Real-time kinetics of gene activity in individual bacteria [J].
Golding, I ;
Paulsson, J ;
Zawilski, SM ;
Cox, EC .
CELL, 2005, 123 (06) :1025-1036
[13]   Transcriptome profiles for high-cell-density recombinant and wild-type Escherichia coli [J].
Haddadin, FT ;
Harcum, SW .
BIOTECHNOLOGY AND BIOENGINEERING, 2005, 90 (02) :127-153
[14]  
HANSEN SR, 1980, SCIENCE, V207, P1491
[15]   EXPRESSION IN ESCHERICHIA-COLI OF A CHEMICALLY SYNTHESIZED GENE FOR HORMONE SOMATOSTATIN [J].
ITAKURA, K ;
HIROSE, T ;
CREA, R ;
RIGGS, AD ;
HEYNEKER, HL ;
BOLIVAR, F ;
BOYER, HW .
SCIENCE, 1977, 198 (4321) :1056-1063
[16]  
JANICK J, 1999, PERSPECTIVES NEW CRO, V4, P104
[17]  
Kassouf Wassim, 2004, Expert Rev Anticancer Ther, V4, P1037, DOI 10.1586/14737140.4.6.1037
[18]  
Kirk T. K., 2004, BIOL CONFINEMENT GEN
[19]   Phenotypic diversity, population growth, and information in fluctuating environments [J].
Kussell, E ;
Leibler, S .
SCIENCE, 2005, 309 (5743) :2075-2078
[20]   Gene regulation: Towards a circuit engineering discipline [J].
McAdams, HH ;
Arkin, A .
CURRENT BIOLOGY, 2000, 10 (08) :R318-R320