Integrated optical microcavities for enhanced evanescent-wave spectroscopy

被引:65
作者
Krioukov, E
Klunder, DJW
Driessen, A
Greve, J
Otto, C
机构
[1] Univ Twente, Res Inst, MESA, Dept Appl Phys,Biophys Tech Grp, NL-7500 AE Enschede, Netherlands
[2] Univ Twente, Res Inst, MESA, Dept Appl Phys,Lightwave Devices Grp, NL-7500 AE Enschede, Netherlands
关键词
D O I
10.1364/OL.27.001504
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
The use of integrated optical microcavities (MCs) for enhanced optical spectroscopy and sensing is investigated. The MC sustains high-Q whispering-gallery modes, in which the energy of the optical field can be efficiently stored. The resulting enhanced field can be used to probe fluorescent molecules in the cladding of the MC, Enhanced fluorescence excitation with an integrated optical MC is demonstrated experimentally for what is believed to be the first time. A comparison between a MC and a straight waveguide shows that the MC may give an increase of 40 times in fluorescence excitation. Because of the ultrasmall size of the MC (15 mum in radius), the fluorescence signal may be observed from only 20 molecules in the cladding. (C) 2002 Optical Society of America.
引用
收藏
页码:1504 / 1506
页数:3
相关论文
共 13 条
[1]   Resonant-enhanced evanescent-wave fluorescence biosensing with cylindrical optical cavities [J].
Blair, S ;
Chen, Y .
APPLIED OPTICS, 2001, 40 (04) :570-582
[2]  
CHANG RK, 1996, OPTICAL PROCESSES MI
[3]   Waveguide Raman spectroscopy of thin polymer layers and monolayers of biomolecules using high refractive index waveguides [J].
Kanger, JS ;
Otto, C ;
Slotboom, M ;
Greve, J .
JOURNAL OF PHYSICAL CHEMISTRY, 1996, 100 (08) :3288-3292
[4]   Vertically and laterally waveguide-coupled cylindrical microresonators in Si3N4 on SiO2 technology [J].
Klunder, DJW ;
Krioukov, E ;
Tan, FS ;
Van Der Veen, T ;
Bulthuis, HF ;
Sengo, G ;
Otto, C ;
Hoekstra, HJWM ;
Driessen, A .
APPLIED PHYSICS B-LASERS AND OPTICS, 2001, 73 (5-6) :603-608
[5]   Sensor based on an integrated optical microcavity [J].
Krioukov, E ;
Klunder, DJW ;
Driessen, A ;
Greve, J ;
Otto, C .
OPTICS LETTERS, 2002, 27 (07) :512-514
[6]   Numerical analysis of the whispering gallery modes by the finite-difference time-domain method [J].
Li, BJ ;
Liu, PL .
IEEE JOURNAL OF QUANTUM ELECTRONICS, 1996, 32 (09) :1583-1587
[7]   ENHANCEMENT OF FLUORESCENCE INDUCED BY MICROSTRUCTURE RESONANCES OF A DIELECTRIC FIBER [J].
OWEN, JF ;
BARBER, PW ;
DORAIN, PB ;
CHANG, RK .
PHYSICAL REVIEW LETTERS, 1981, 47 (15) :1075-1078
[8]   Absorption and fluorescence spectroscopic investigation of indocyanine green [J].
Philip, R ;
Penzkofer, A ;
Baumler, W ;
Szeimies, RM ;
Abels, C .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 1996, 96 (1-3) :137-148
[9]   Femtomolar sensitivity using a channel-etched thin film waveguide fluoroimmunosensor [J].
Plowman, TE ;
Reichert, WM ;
Peters, CR ;
Wang, HK ;
Christensen, DA ;
Herron, JN .
BIOSENSORS & BIOELECTRONICS, 1996, 11 (1-2) :149-160
[10]   Planar integrated optical methods for examining thin films and their surface adlayers [J].
Plowman, TE ;
Saavedra, SS ;
Reichert, WM .
BIOMATERIALS, 1998, 19 (4-5) :341-355