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In-water reactivity of nucleosides and nucleotides:: one-step preparation and biological evaluation of novel ferrocenyl-derivatives

被引：15
作者：
de Champdoré, M
Di Fabio, G
Messere, A
Montesarchio, D
Piccialli, G
Loddo, R
La Colla, M
La Colla, P
机构：
[1] Univ Naples Federico II, Dipartimento Chim Organ & Biochim, I-80126 Naples, Italy
[2] Univ Naples 2, Dipartimento Sci Ambientali, I-81100 Caserta, Italy
[3] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy
[4] Univ Cagliari, Dipartimento Sci & Tecnol Biomed, I-09042 Monserrato, Italy
来源：
TETRAHEDRON | 2004年 / 60卷 / 31期
关键词：
nucleosides; nucleotides; ferrocene derivatives; biological activity;
D O I：
10.1016/j.tet.2004.06.013
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reactivity in water of a series of nucleosides and nucleotides towards ferrocenemethanol was investigated. Several adducts incorporating the ferrocenemethyl moiety into the heterocyclic base were isolated and their activity was tested against HIV-1, HBV, YFV, BVDV and several bacteria. However, none of the new compounds showed significant antiviral activity nor cytotoxicity. The reaction with ferrocenemethanol of the model dinucleotide (5')dCpdG(3'), for a direct comparison of the behaviour of purine versus pyrimidine bases, is also discussed. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：6555 / 6563
页数：9
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