Expression of metabotropic glutamate receptor subtype mRNA (mGluR1-8) in human cerebellum

被引：60

作者：

Berthele, A

Platzer, S

Laurie, DJ

Weis, S

Sommer, B

Zieglgänsberger, W

Conrad, B

Tölle, TR

机构：

[1] Tech Univ Munich, Dept Neurol, D-81675 Munich, Germany

[2] Max Planck Inst Psychiat, D-80804 Munich, Germany

[3] Novartis Pharma AG, CH-4002 Basel, Switzerland

[4] Otto Von Guericke Univ, Dept Neuropathol, D-39120 Magdeburg, Germany

来源：

NEUROREPORT | 1999年 / 10卷 / 18期

关键词：

human cerebellum; in situ hybridization; metabotropic glutamate receptor; mRNA expression; oligodeoxynucleotide probes;

D O I：

10.1097/00001756-199912160-00026

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE expression of metabotropic glutamate receptor (mGluR) mRNAs in the human cerebellar neocortex was investigated using in situ hybridization. mGluR1, 3 and 4 mRNAs were most abundant and widely distributed, whereas mGluR2, 5 and 7 mRNA expression was circumscript, mRNAs coding for mGluR1, 3, 4 and 7 were expressed in Purkinje cells. mGluR1 and 4 mRNAs detectable in granule cells and mGluR1, 2, 3, 4 and 7 mRNAs in Golgi cells, mGluR5 mRNA was detectable in putative Bergmann glia as well as mGluR3 mRNA, which was widely expressed in glial cells. mGluR8 mRNA expression was very low in a subset of stellate/basket cells of the molecular layer whereas mGluR6 mRNA was not detectable in the cerebellar cortex. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：3861 / 3867

页数：7

共 25 条

[21] Immunohistochemical localisation of mGluR7 protein in the rodent and human cerebellar cortex using subtype specific antibodies [J].