IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses

被引：126

作者：

Schellack, Carola

Prinz, Karin

Egyed, Alena

Fritz, Jorg H.

Wittmann, Barbara

Ginzler, Michael

Swatosch, Gabriele

Zauner, Wolfgang

Kast, Constantia

Akira, Shizuo

von Gabain, Alexander

Buschle, Michael

Lingnau, Karen

机构：

[1] Intercell AG, A-1030 Vienna, Austria

[2] Inst Pasteur, Unite Immunite Innee & Signalisat, F-75015 Paris, France

[3] Osaka Univ, Dept Host Def, Res Inst Microbial Dis, Suita, Osaka 5650871, Japan

来源：

VACCINE | 2006年 / 24卷 / 26期

关键词：

vaccine; CTL; antibodies;

D O I：

10.1016/j.vaccine.2006.03.071

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IC31, the combination of a novel immunostimulatory oligodeoxynucleotide containing deoxy-Inosine/deoxy-Cytosine (ODN1a) and the antimicrobial peptide KLKL5KLK, represents a promising novel adjuvant signaling via the TLR9/MyD88-dependent pathway of the innate immune system. In mice, IC31 induces potent peptide-specific type 1 cellular immune responses, as well as mainly type 1 dominated proteinspecific cellular and humoral immune responses. In addition, cytotoxic T lymphocytes were induced, able to kill efficiently target cells in vivo. Activation of murine dendritic cells by IC31 induced efficiently proliferation of naive CD4(+) TCR transgenic T cells (DO. 11.10) as well as their differentiation into IFN-gamma- and IL-4-producing T cells in vitro. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5461 / 5472

页数：12

共 32 条

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