Copper(I) thiolate catalysts in asymmetric conjugate addition reactions

被引：44

作者：

Arink, AM

Braam, TW

Keeris, R

Jastrzebski, JTBH

Benhaim, C

Rosset, S

Alexakis, A

van Koten, G

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

[2] Univ Utrecht, Debye Inst, Dept Met Mediated Synth, NL-3584 CH Utrecht, Netherlands

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 12期

关键词：

D O I：

10.1021/ol049457u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Full conversion and en antioselectivities up to 83% have been obtained in the conjugate addition reactions of diethyl zinc to Michael acceptors catalyzed by well-defined (chiral) copper(I) aminoarenethiolates. Interesting differences between organozinc or Grignard reagents have been found: for cyclic enones R2Zn reagents afford better results, whereas earlier work showed that RMgX reagents react more selectively with acyclic enones.

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页码：1959 / 1962

页数：4

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