Polypeptide-polymer bioconjugates

被引：215

作者：

Canalle, Luiz A. ^{[1
]}

Lowik, Dennis W. P. M. ^{[1
]}

van Hest, Jan C. M. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 AJ Nijmegen, Netherlands

来源：

CHEMICAL SOCIETY REVIEWS | 2010年 / 39卷 / 01期

关键词：

SITE-SPECIFIC PEGYLATION; SOLID-PHASE SYNTHESIS; HYBRID BLOCK-COPOLYMERS; TRANSFER RADICAL POLYMERIZATION; SIDE-CHAIN POLYMERS; TRACELESS STAUDINGER LIGATION; MICROWAVE-ASSISTED SYNTHESIS; FREE TRIAZOLE FORMATION; POLYETHYLENE-GLYCOL; POLY(ETHYLENE GLYCOL);

D O I：

10.1039/b807871h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Creating bioconjugates by combining polymers with peptides and proteins is an emerging multidisciplinary field of research that has enjoyed increased attention within the scientific community. This critical review provides an overview of the strategies employed for the construction of these materials and will highlight the underlying synthetic methods used. This review is therefore relevant for chemists, material scientists and chemical biologists facing the challenge of constructing polypeptide-polymer bioconjugates in a controlled fashion (269 references).

引用

页码：329 / 353

页数：25

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