Biodegradable nanoparticles for drug delivery and targeting

被引：1000

作者：

Hans, ML ^{[1
]}

Lowman, AM ^{[1
]}

机构：

[1] Drexel Univ, Dept Chem Engn, Biomat & Drug Delivery Lab, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE | 2002年 / 6卷 / 04期

关键词：

nanoparticles; PLGA; drug delivery; surface modifications;

D O I：

10.1016/S1359-0286(02)00117-1

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Throughout the world today, numerous researchers are exploring the potential use of polymeric nanoparticles as carriers for a wide range of drugs for therapeutic applications. Because of their versatility and wide range of properties, biodegradable polymeric nanoparticles are being used as novel drug delivery systems. In particular, this class of carrier holds tremendous promise in the areas of cancer therapy and controlled delivery of vaccines. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：319 / 327

页数：9

共 50 条

[21] Sulfobutylated poly(vinyl alcohol)-graft-poly(lactide-co-glycolide)s facilitate the preparation of small negatively charged biodegradable nanospheres [J].

Jung, T ;

Breitenbach, A ;

Kissel, T .

JOURNAL OF CONTROLLED RELEASE, 2000, 67 (2-3) :157-169

[22] Nanoparticulate systems for brain delivery of drugs [J].

Kreuter, J .

ADVANCED DRUG DELIVERY REVIEWS, 2001, 47 (01) :65-81

[23] Preparation of PLGA nanoparticles containing estrogen by emulsification-diffusion method [J].

Kwon, HY ;

Lee, JY ;

Choi, SW ;

Jang, YS ;

Kim, JH .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2001, 182 (1-3) :123-130

[24] Nanoparticulate systems for the delivery of antisense oligonucleotides [J].

Lambert, G ;

Fattal, E ;

Couvreur, P .

ADVANCED DRUG DELIVERY REVIEWS, 2001, 47 (01) :99-112

[25] Polymeric nanoparticles as delivery system for influenza virus glycoproteins [J].

Lemoine, D ;

Preat, V .

JOURNAL OF CONTROLLED RELEASE, 1998, 54 (01) :15-27

[26] Biodegradable nanoparticles - From sustained release formulations to improved site specific drug delivery [J].

Leroux, JC ;

Allemann, E ;

DeJaeghere, F ;

Doelker, E ;

Gurny, R .

JOURNAL OF CONTROLLED RELEASE, 1996, 39 (2-3) :339-350

[27] PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats [J].

Li, YP ;

Pei, YY ;

Zhang, XY ;

Gu, ZH ;

Zhou, ZH ;

Yuan, WF ;

Zhou, JJ ;

Zhu, JH ;

Gao, XJ .

JOURNAL OF CONTROLLED RELEASE, 2001, 71 (02) :203-211

[28] Preparation of nanoparticles consisted of poly(L-lactide)-poly(ethylene glycol)-poly(L-lactide) and their evaluation in vitro [J].

Matsumoto, J ;

Nakada, Y ;

Sakurai, K ;

Nakamura, T ;

Takahashi, Y .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1999, 185 (01) :93-101

[29] Nanosuspensions as particulate drug formulations in therapy Rationale for development and what we can expect for the future [J].

Muller, RH ;

Jacobs, C ;

Kayser, O .

ADVANCED DRUG DELIVERY REVIEWS, 2001, 47 (01) :3-19

[30] Preparation of poly(DL-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method [J].

Murakami, H ;

Kobayashi, M ;

Takeuchi, H ;

Kawashima, Y .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1999, 187 (02) :143-152

← 1 2 3 4 5 →