Biodegradable nanoparticles for drug delivery and targeting

被引：1000

作者：

Hans, ML ^{[1
]}

Lowman, AM ^{[1
]}

机构：

[1] Drexel Univ, Dept Chem Engn, Biomat & Drug Delivery Lab, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE | 2002年 / 6卷 / 04期

关键词：

nanoparticles; PLGA; drug delivery; surface modifications;

D O I：

10.1016/S1359-0286(02)00117-1

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Throughout the world today, numerous researchers are exploring the potential use of polymeric nanoparticles as carriers for a wide range of drugs for therapeutic applications. Because of their versatility and wide range of properties, biodegradable polymeric nanoparticles are being used as novel drug delivery systems. In particular, this class of carrier holds tremendous promise in the areas of cancer therapy and controlled delivery of vaccines. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：319 / 327

页数：9

共 50 条

[41] Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery [J].

Song, CX ;

Labhasetwar, V ;

Murphy, H ;

Qu, X ;

Humphrey, WR ;

Shebuski, RJ ;

Levy, RJ .

JOURNAL OF CONTROLLED RELEASE, 1997, 43 (2-3) :197-212

[42] Biodegradable polymeric nanoparticles as drug delivery devices [J].

Soppimath, KS ;

Aminabhavi, TM ;

Kulkarni, AR ;

Rudzinski, WE .

JOURNAL OF CONTROLLED RELEASE, 2001, 70 (1-2) :1-20

[43]

Suh HR, 1998, J BIOMED MATER RES, V42, P331, DOI 10.1002/(SICI)1097-4636(199811)42:2<331::AID-JBM19>3.0.CO

[44]

2-L

[45] Mucoadhesive nanoparticulate systems for peptide drug delivery [J].

Takeuchi, H ;

Yamamoto, H ;

Kawashima, Y .

ADVANCED DRUG DELIVERY REVIEWS, 2001, 47 (01) :39-54

[46] The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration [J].

Tobío, M ;

Sánchez, A ;

Vila, A ;

Soriano, I ;

Evora, C ;

Vila-Jato, JL ;

Alonso, MJ .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2000, 18 (3-4) :315-323

[47] Ex vivo and in situ PLGA microspheres uptake by pig ileal Peyer's patch segment [J].

Torché, AM ;

Jouan, H ;

Le Corre, P ;

Albina, E ;

Primault, R ;

Jestin, A ;

Le Verge, R .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2000, 201 (01) :15-27

[48]

VERGER MLL, 1998, EUR J PHARM BIOPHARM, V46, P137

[49] Design of biodegradable particles for protein delivery [J].

Vila, A ;

Sánchez, A ;

Tobío, M ;

Calvo, P ;

Alonso, MJ .

JOURNAL OF CONTROLLED RELEASE, 2002, 78 (1-3) :15-24

[50] In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates [J].

Yoo, HS ;

Lee, KH ;

Oh, JE ;

Park, TG .

JOURNAL OF CONTROLLED RELEASE, 2000, 68 (03) :419-431

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