Polyomaviruses and human cancer: molecular mechanisms underlying patterns of tumorigenesis

被引：125

作者：

White, MK ^{[1
]}

Khalili, K ^{[1
]}

机构：

[1] Temple Univ, Coll Sci & Technol, Ctr Neurovirol & Canc Biol, Philadelphia, PA 19122 USA

来源：

VIROLOGY | 2004年 / 324卷 / 01期

关键词：

polyomaviruses; human cancer; tumorigenesis;

D O I：

10.1016/j.virol.2004.03.025

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Polyomaviruses are DNA tumor viruses with small circular genomes encoding only six proteins including three structural capsid proteins. Despite this simplicity, Our understanding of the mechanisms of polyomavirus-mediated tumorigenesis is far from complete. The archetypal primate polyomavirus, SV40, was isolated more than 40 years ago and has been used extensively as a model system for the study of basic eukaryotic cellular processes such as DNA replication and transcription. Two human polyomaviruses have been isolated from clinical samples: JC virus (JCV) and BK virus (BKV). In this review, SV40, JCV, and BKV will be compared based on what is known about their molecular biology from experiments performed in vitro, in cell culture and in laboratory animals. The association of these viruses with clinical tumors is discussed along with the possible roles of these polyomaviruses in the etiology of human malignant disease. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：1 / 16

页数：16

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