Competitive Interactions Between Cells: Death, Growth, and Geography

被引：170

作者：

Johnston, Laura A. ^{[1
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA

来源：

SCIENCE | 2009年 / 324卷 / 5935期

关键词：

RIBOSOMAL-RNA SYNTHESIS; GERMLINE STEM-CELLS; DROSOPHILA-OVARY; MYC; NICHE; TRANSCRIPTION; COMPARTMENTS; GENES; PROLIFERATION; APOPTOSIS;

D O I：

10.1126/science.1163862

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Competitive interactions between cells are the basis of many homeostatic processes in biology. Some of the best-described cases of competition between cells occur in Drosophila: cell competition, whereby somatic cells within a growing epithelium compete with one another for contribution to the adult, and stem cell competition, in which germline or somatic stem cells vie for residency in the niche. Both types of competition are conserved physiological processes, with much to tell us about how cellular neighborhoods influence cell behavior, and have importance to stem cell biology, regeneration and transplantation, and cancer.

引用

页码：1679 / 1682

页数：4

共 39 条

[1] Morphogenetic apoptosis: A mechanism for correcting discontinuities in morphogen gradients [J].

Adachi-Yamada, T ;

O'Connor, MB .

DEVELOPMENTAL BIOLOGY, 2002, 251 (01) :74-90

[2] Cell competition and its possible relation to cancer [J].

Baker, Nicholas E. ;

Li, Wei .

CANCER RESEARCH, 2008, 68 (14) :5505-5507

[3] INTRINSIC AND EXTRINSIC CONTROL OF GROWTH IN DEVELOPING ORGANS [J].

BRYANT, PJ ;

SIMPSON, P .

QUARTERLY REVIEW OF BIOLOGY, 1984, 59 (04) :387-415

[4]

Burke R, 1996, DEVELOPMENT, V122, P2261

[5] Analysis of C-MYC function in normal cells via conditional gene-targeted mutation [J].

de Alboran, IM ;

O'Hagan, RC ;

Gärtner, F ;

Malynn, B ;

Davidson, L ;

Rickert, R ;

Rajewsky, K ;

DePinho, RA ;

Alt, FW .

IMMUNITY, 2001, 14 (01) :45-55

[6] Drosophila Myc regulates organ size by inducing cell competition [J].

de la Cova, C ;

Abril, M ;

Bellosta, P ;

Gallant, P ;

Johnston, LA .

CELL, 2004, 117 (01) :107-116

[7] Myc in model organisms: A view from the flyroom [J].

de la Cova, Claire ;

Johnston, Laura A. .

SEMINARS IN CANCER BIOLOGY, 2006, 16 (04) :303-312

[8] c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I [J].

Grandori, C ;

Gomez-Roman, N ;

Felton-Edkins, ZA ;

Ngouenet, C ;

Galloway, DA ;

Eisenman, RN ;

White, RJ .

NATURE CELL BIOLOGY, 2005, 7 (03) :311-U121

[9] Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development [J].

Grewal, SS ;

Li, L ;

Orian, A ;

Eisenman, RN ;

Edgar, BA .

NATURE CELL BIOLOGY, 2005, 7 (03) :295-U109

[10] Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary [J].

Jin, Zhigang ;

Kirilly, Daniel ;

Weng, Changjiang ;

Kawase, Eihachiro ;

Song, Xiaoqing ;

Smith, Sarah ;

Schwartz, Joel ;

Xie, Ting .

CELL STEM CELL, 2008, 2 (01) :39-49

← 1 2 3 4 →