Effects of Unilateral Nephrectomy on Renal Function in Male Spontaneously Diabetic Torii Fatty Rats: A Novel Obese Type 2 Diabetic Model

被引：9

作者：

Katsuda, Yoshiaki ^{[1
]}

Kemmochi, Yusuke ^{[2
]}

Maki, Mimi ^{[1
]}

Sano, Ryuhei ^{[1
]}

Toriniwa, Yasufumi ^{[1
]}

Ishii, Yukihito ^{[1
]}

Miyajima, Katsuhiro ^{[2
]}

Kakimoto, Kochi ^{[2
]}

Ohta, Takeshi ^{[1
]}

机构：

[1] Japan Tobacco Inc, Cent Pharmaceut Res Inst, Biol Pharmacol Res Labs, Takatsuki, Osaka 5691125, Japan

[2] Japan Tobacco Inc, Cent Pharmaceut Res Inst, Toxicol Res Labs, Kanagawa 2570024, Japan

来源：

JOURNAL OF DIABETES RESEARCH | 2014年 / 2014卷

关键词：

BLOOD-PRESSURE; GLOMERULAR HEMODYNAMICS; KIDNEY-DISEASE; COMPLICATIONS; NEPHROPATHY; PROGRESSION; FAILURE; INJURY; RISK;

D O I：

10.1155/2014/363126

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The Spontaneously Diabetic Torii (SDT) fatty rat is a new model for obese type 2 diabetes. The aim of the present study was to investigate the effect of 1/2 nephrectomy (Nx) on renal function and morphology and on blood pressure in SDT fatty rats. Male SDT fatty rats underwent 1/2 Nx or a shamoperation (Sham). Subsequently, animals were studied with respect to renal function and histological alterations. Induction of 1/2 Nx in SDT fatty rats led to functional and morphological damage to the remnant kidney and to hypertension, which are considered main characteristics of chronic kidney disease, at a younger age compared with the sham group. In conclusion, the SDT fatty rat is useful in investigations to elucidate the pathogenesis of human diabetic nephropathy and in new drug discovery.

引用

页数：6

共 26 条

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