Effect of fenofibrate on brachial artery flow-mediated dilatation in type 2 diabetes mellitus

被引：67

作者：

Playford, DA ^{[1
]}

Watts, GF ^{[1
]}

Best, JD ^{[1
]}

Burke, V ^{[1
]}

机构：

[1] Univ Western Australia, Royal Perth Hosp, Dept Med, Perth, WA 6847, Australia

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2002年 / 90卷 / 11期

关键词：

D O I：

10.1016/S0002-9149(02)02847-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Forty patients with type 2 diabetes and dyslipidemia were randomized in a double-blind study to receive fenofibrate or placebo for 12 weeks. Brachial artery flow-mediated dilatation improved in response to fenofibrate but not placebo, with changes partly related to improvements in plasma lipid and lipoprotein concentrations.

引用

页码：1254 / +

页数：5

共 21 条

[11]

OBrien SF, 1997, DIABETIC MED, V14, P974, DOI 10.1002/(SICI)1096-9136(199711)14:11<974::AID-DIA495>3.0.CO

[12]

2-I

[13] Special article: Non-invasive measurement of endothelial function [J].

Playford, DA ;

Watts, GF .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1998, 25 (7-8) :640-643

[14] Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol [J].

Rubins, HB ;

Robins, SJ ;

Collins, D ;

Fye, CL ;

Anderson, JW ;

Elam, MB ;

Faas, FH ;

Linares, E ;

Schaefer, EJ ;

Schectman, G ;

Wilt, TJ ;

Wittes, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (06) :410-418

[15] EXERCISE-INDUCED VASOMOTION OF ANGIOGRAPHICALLY NORMAL AND STENOTIC CORONARY-ARTERIES IMPROVES AFTER CHOLESTEROL-LOWERING DRUG-THERAPY WITH BEZAFIBRATE [J].

SEILER, C ;

SUTER, TM ;

HESS, OM .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1995, 26 (07) :1615-1622

[16]

Steiner G, 2001, LANCET, V357, P905

[17] Impaired endothelium dependent and independent dilatation of forearm resistance arteries in men with diet-treated non-insulin-dependent diabetes: Role of dyslipidaemia [J].

Watts, GF ;

OBrien, SF ;

Silvester, W ;

Millar, JA .

CLINICAL SCIENCE, 1996, 91 (05) :567-573

[18] Dyslipoproteinaemia and hyperoxidative stress in the pathogenesis of endothelial dysfunction in non-insulin dependent diabetes mellitus: an hypothesis [J].

Watts, GF ;

Playford, DA .

ATHEROSCLEROSIS, 1998, 141 (01) :17-30

[19] Fibrates, dyslipoproteinaemia and cardiovascular disease [J].

Watts, GF ;

Dimmitt, SB .

CURRENT OPINION IN LIPIDOLOGY, 1999, 10 (06) :561-574

[20] Effect of statin versus fibrate on postprandial endothelial dysfunction: role of remnant-like particles [J].

Wilmink, HW ;

Twickler, MB ;

Banga, JD ;

Dallinga-Thie, GM ;

Eeltink, H ;

Erkelens, DW ;

Rabelink, TJ ;

Stroes, ES .

CARDIOVASCULAR RESEARCH, 2001, 50 (03) :577-582

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