Gene expression profiling and clinical outcome in breast cancer

被引：42

作者：

Bertucci, Francois ^{[1
]}

Finetti, Pascal ^{[1
]}

Cervera, Nathalie ^{[1
]}

Maraninchi, Dominique ^{[1
]}

Viens, Patrice ^{[1
]}

Birnbaum, Daniel ^{[1
]}

机构：

[1] Univ Mediterranee, Inst J Paoli I Calmettes, INSERM UMR 599, Ctr Rech Cancerol Marseille,Dept Oncol Med, F-13273 Marseille 9, France

来源：

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY | 2006年 / 10卷 / 04期

关键词：

D O I：

10.1089/omi.2006.10.429

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Pathologic and clinical heterogeneity of breast cancer reflects the poorly documented, complex, and combinatory molecular basis of the disease and is in part responsible for therapeutic failures. The DNA microarray technique allows the analysis of RNA expression of several thousands of genes simultaneously in a sample. There are multiple potential applications of the technique in cancer research. A number of recent studies have shown the promising role of gene expression profiling in breast cancer by identifying new prognostic subclasses unidentifiable by conventional parameters and new prognostic and/or predictive gene signatures, whose predictive impact is superior to conventional histoclinical prognostic factors. In this review we describe current use of DNA microarrays in the prognosis of breast cancer. We also discuss issues that need to be addressed in the near future to allow the method to reach its full potential.

引用

页码：429 / 443

页数：15

共 86 条

[11] Breast cancer revisited using DNA array-based gene expression profiling [J].

Bertucci, F ;

Viens, P ;

Hingamp, P ;

Nasser, V ;

Houlgatte, R ;

Birnbaum, D .

INTERNATIONAL JOURNAL OF CANCER, 2003, 103 (05) :565-571

[12] Gene expression profiles of poor-prognosis primary breast cancer correlate with survival [J].

Bertucci, F ;

Nasser, V ;

Granjeaud, S ;

Eisinger, F ;

Adelaïde, J ;

Tagett, R ;

Loriod, A ;

Giaconia, A ;

Benziane, A ;

Devilard, E ;

Jacquemier, J ;

Viens, P ;

Nguyen, C ;

Birnbaum, D ;

Houlgatte, R .

HUMAN MOLECULAR GENETICS, 2002, 11 (08) :863-872

[13] Gene expression profiling of primary breast carcinomas using arrays of candidate genes [J].

Bertucci, F ;

Houlgatte, R ;

Benziane, A ;

Granjeaud, S ;

Adélaïde, J ;

Tagett, R ;

Loriod, B ;

Jacquemier, J ;

Viens, P ;

Jordan, B ;

Birnbaum, D ;

Nguyen, C .

HUMAN MOLECULAR GENETICS, 2000, 9 (20) :2981-2991

[14] Proteomics of breast cancer - Principles and potential clinical applications [J].

Bertucci, Francois ;

Birnbaum, Daniel ;

Goncalves, Anthony .

MOLECULAR & CELLULAR PROTEOMICS, 2006, 5 (10) :1772-1786

[15] Gene expression data analysis [J].

Brazma, A ;

Vilo, J .

FEBS LETTERS, 2000, 480 (01) :17-24

[16] Global gene expression changes during neoadjuvant chemotherapy for human breast cancer [J].

Buchholz, TA ;

Stivers, DN ;

Stec, J ;

Ayers, M ;

Clark, E ;

Bolt, A ;

Sahin, AA ;

Symmans, WF ;

Hess, KR ;

Kuerer, HM ;

Valero, V ;

Hortobagyi, GN ;

Pusztai, L .

CANCER JOURNAL, 2002, 8 (06) :461-468

[17] Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study [J].

Carey, Lisa A. ;

Perou, Charles M. ;

Livasy, Chad A. ;

Dressler, Lynn G. ;

Cowan, David ;

Conway, Kathleen ;

Karaca, Gamze ;

Troester, Melissa A. ;

Tse, Chiu Kit ;

Edmiston, Sharon ;

Deming, Sandra L. ;

Geradts, Joseph ;

Cheang, Maggie C. U. ;

Nielsen, Torsten O. ;

Moorman, Patricia G. ;

Earp, H. Shelton ;

Millikan, Robert C. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (21) :2492-2502

[18] Redefinition of affymetrix probe sets by sequence overlap with cDNA microarray probes reduces cross-platform inconsistencies in cancer-associated gene expression measurements [J].

Carter, SL ;

Eklund, AC ;

Mecham, BH ;

Kohane, IS ;

Szallasi, Z .

BMC BIOINFORMATICS, 2005, 6 (1)

[19] Patterns of resistance and incomplete response to docetaxel by gene expression profiling in breast cancer patients [J].

Chang, JC ;

Wooten, EC ;

Tsimelzon, A ;

Hilsenbeck, SG ;

Gutierrez, MC ;

Tham, YL ;

Kalidas, M ;

Elledge, R ;

Mohsin, S ;

Osborne, CK ;

Chamness, GC ;

Allred, DC ;

Lewis, MT ;

Wong, H ;

O'Connell, P .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (06) :1169-1177

[20] Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer [J].

Chang, JC ;

Wooten, EC ;

Tsimelzon, A ;

Hilsenbeck, SG ;

Gutierrez, MC ;

Elledge, R ;

Mohsin, S ;

Osborne, CK ;

Chamness, GC ;

Allred, DC ;

O'Connell, P .

LANCET, 2003, 362 (9381) :362-369

← 1 2 3 4 5 6 7 8 9 →