Hydrodynamics of a DNA molecule in a flow field

被引：168

作者：

Larson, RG ^{[1
]}

Perkins, TT ^{[1
]}

Smith, DE ^{[1
]}

Chu, S ^{[1
]}

机构：

[1] STANFORD UNIV,DEPT PHYS,STANFORD,CA 94305

来源：

PHYSICAL REVIEW E | 1997年 / 55卷 / 02期

关键词：

D O I：

10.1103/PhysRevE.55.1794

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

The hydrodynamics of a single, fluorescing, DNA molecule held at one end by ''optical tweezers'' and subjected to a uniform flow are compared with Monte Carlo simulations that account for the molecule's entropic elasticity, Brownian motion, and hydrodynamic drag. Using self-diffusion data and analytic expressions to obtain the drag in the limits of the undeformed coil and of the fully stretched thread, the predicted chain stretching and mass distribution are in quantitative agreement with measurements. The results explain the success of the nonlinear elastic ''dumbbell'' model in predicting the rheological properties of dilute polymer solutions.

引用

页码：1794 / 1797

页数：4

共 29 条

[21] DNA - A MODEL-COMPOUND FOR SOLUTION STUDIES OF MACROMOLECULES [J].