Prostanoids and free radicals in Cl4C-induced hepatotoxicity in rats: Effect of astilbin

被引：58

作者：

Closa, D

Torres, M

Hotter, G

Bioque, G

Leon, OS

Gelpi, E

RoselloCatafau, J

机构：

[1] CSIC,CID,DEPT MED BIOANAL,ES-08034 BARCELONA,SPAIN

[2] UNIV LA HABANA,INST FARM,CTR CONTROL BIOL,HAVANA,CUBA

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1997年 / 56卷 / 04期

关键词：

D O I：

10.1016/S0952-3278(97)90578-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A beneficial effect of flavonoids in Cl4C-induced hepatoxicity in rats has been reported, In this communication we have evaluated the protective effect of astilbin, an active flavonoid isolated from a crude extract of Hymenaea martiana, as well as its action on liver arachidonate metabolism in Cl4C-treated rats. The following groups of rats were studied: Group I = controls; Group II = Astilbine-treated animals (40 mg/Kg); Group III = Cl4C-treated at 1 ml/kg; Group IV = Astilbine + ClC4 and Group V = Vitamine E (50 mg/Kg) + Cl4C-treated animals. Histological findings, superoxide dismutase activity, lipoperoxides and prostanoid profiling studies revealed that the hepatoprotective effect of astilbine was higher than that of vitamin E. Astilbine was capable to restore lipoperoxides and tissue prostanoids to basal values.

引用

页码：331 / 334

页数：4

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