Drug-induced hyperuricaemia and gout

被引：235

作者：

Ben Salem, C. ^{[1
]}

Slim, Raoudha ^{[1
]}

Fathallah, Neila ^{[1
]}

Hmouda, Houssem ^{[2
]}

机构：

[1] Fac Med Sousse, Dept Pharmacovigilance, Ave Mohamed Karoui, Sousse 4002, Tunisia

[2] Sahloul Univ Hosp, Med Intens Care Unit, Sousse, Tunisia

来源：

RHEUMATOLOGY | 2017年 / 56卷 / 05期

关键词：

hyperuricaemia; gout; drug-induced; uric acid; diuretics; organic anion transporters; prevention; management; SERUM URIC-ACID; TUMOR LYSIS SYNDROME; PYRAZINAMIDE-INDUCED HYPERURICEMIA; ETHAMBUTOL-INDUCED HYPERURICEMIA; RENAL-TRANSPLANT PATIENTS; URATE EFFLUX TRANSPORTER; NICOTINIC-ACID; INCIDENT GOUT; HYPERTENSIVE PATIENTS; LACTATE INFUSION;

D O I：

10.1093/rheumatology/kew293

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Hyperuricaemia is a common clinical condition that can be defined as a serum uric acid level >6.8 mg/dl (404 mu mol/l). Gout, a recognized complication of hyperuricaemia, is the most common inflammatory arthritis in adults. Drug-induced hyperuricaemia and gout present an emergent and increasingly prevalent problem in clinical practice. Diuretics are one of the most important causes of secondary hyperuricaemia. Drugs raise serum uric acid level by an increase of uric acid reabsorption and/or decrease in uric acid secretion. Several drugs may also increase uric acid production. In this review, drugs leading to hyperuricaemia are summarized with regard to their mechanism of action and clinical significance. Increased awareness of drugs that can induce hyperuricaemia and gout, and monitoring and prevention are key elements for reducing the morbidity related to drug-induced hyperuricaemia and gout.

引用

页码：679 / 688

页数：10

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