One-pot three-component reaction for the synthesis of α-(aminoethyl)-α,β-enones

被引：38

作者：

Bertozzi, F ^{[1
]}

Gustafsson, M ^{[1
]}

Olsson, R ^{[1
]}

机构：

[1] ACADIA Pharmaceut AS, Discovery Chem, DK-2600 Glostrup, Denmark

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 24期

关键词：

D O I：

10.1021/ol026976t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

graphic The synthesis of alpha-substituted alpha,beta-enones by a new metal iodide-promoted one-pot three-component reaction involving commercially available cyclopropyl ketones, aldehydes, and secondary amines followed by base treatment is described.

引用

页码：4333 / 4336

页数：4

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