EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia

被引:104
作者
So, CW
Caldas, C
Liu, MM
Chen, SJ
Huang, QH
Gu, LJ
Sham, MH
Wiedemann, LM
Chan, LC
机构
[1] UNIV HONG KONG, DEPT PATHOL, HONG KONG, HONG KONG
[2] UNIV HONG KONG, DEPT BIOCHEM, HONG KONG, HONG KONG
[3] INST CANC RES, LEUKAEMIA RES FUND CTR, LONDON SW3 6JB, ENGLAND
[4] SHANGHAI MED UNIV 2, XIN HUA HOSP, SHANGHAI 200025, PEOPLES R CHINA
[5] KEY LAB HUMAN GENOME RES, SHANGHAI 200025, PEOPLES R CHINA
[6] SHANGHAI INST HAEMATOL, SHANGHAI 200025, PEOPLES R CHINA
关键词
D O I
10.1073/pnas.94.6.2563
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The MLL gene, the closest human homologue to the Drosophila trithorax gene, undergoes chromosomal translocation with a large number of different partner genes in both acute lymphoid and acute myeloid leukemias, We have identified a new partner gene, EEN, fused to MLL in a case of acute myeloid leukemia, The gene is located on chromosome 19p13, where two other MLL partner genes, ENL and ELL/MEN have also been identified, The deduced protein of 368 aa contains a central cy-helical region and a C-terminal Src homology 3 (SH3) domain most similar to the C-terminal SH3 domain found in the Grb2/Sem-5/Drk family of genes, Sequence analysis of the fusion MLL/EEN transcript in our patient reveals that exon 6 of MLL is fused to the N-terminal end of EEN, a fusion that would create a chimeric protein that includes the major functional domain of EEN, EEN is expressed in a variety of tissue types and encodes a protein of approximately 46 kDa, The EEN protein is the human homologue of a member of a recently described murine SH3 domain-containing protein family, It is also highly related to a putative gene identified in Caenorhabditis elegans, and a number of similar sequences are present in the EST databases of several species.
引用
收藏
页码:2563 / 2568
页数:6
相关论文
共 52 条
  • [41] Cloning of ligand targets: Systematic isolation of SH3 domain-containing proteins
    Sparks, AB
    Hoffman, NG
    McConnell, SJ
    Fowlkes, DM
    Kay, BK
    [J]. NATURE BIOTECHNOLOGY, 1996, 14 (06) : 741 - 744
  • [42] A CONSENSUS SEQUENCE FOR CLEAVAGE BY VERTEBRATE DNA TOPOISOMERASE-II
    SPITZNER, JR
    MULLER, MT
    [J]. NUCLEIC ACIDS RESEARCH, 1988, 16 (12) : 5533 - 5556
  • [43] STOCK W, 1994, LEUKEMIA, V8, P1918
  • [44] HUMAN ACUTE-LEUKEMIA CELL-LINE WITH THE T(4 - 11) CHROMOSOMAL REARRANGEMENT EXHIBITS B-LINEAGE AND MONOCYTIC CHARACTERISTICS
    STONG, RC
    KORSMEYER, SJ
    PARKIN, JL
    ARTHUR, DC
    KERSEY, JH
    [J]. BLOOD, 1985, 65 (01) : 21 - 31
  • [45] CLONING OF ELL, A GENE THAT FUSES TO MLL IN A T(11-19)(Q23-P13.1) IN ACUTE MYELOID-LEUKEMIA
    THIRMAN, MJ
    LEVITAN, DA
    KOBAYASHI, H
    SIMON, MC
    ROWLEY, JD
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (25) : 12110 - 12114
  • [46] INVOLVEMENT OF A HOMOLOG OF DROSOPHILA-TRITHORAX BY 11Q23 CHROMOSOMAL TRANSLOCATIONS IN ACUTE LEUKEMIAS
    TKACHUK, DC
    KOHLER, S
    CLEARY, ML
    [J]. CELL, 1992, 71 (04) : 691 - 700
  • [47] VANIN EF, 1985, ANNU REV GENET, V19, P253, DOI 10.1146/annurev.genet.19.1.253
  • [48] A SURVEY OF EXPRESSED GENES IN CAENORHABDITIS-ELEGANS
    WATERSTON, R
    MARTIN, C
    CRAXTON, M
    HUYNH, C
    COULSON, A
    HILLIER, L
    DURBIN, R
    GREEN, P
    SHOWNKEEN, R
    HALLORAN, N
    METZSTEIN, M
    HAWKINS, T
    WILSON, R
    BERKS, M
    DU, Z
    THOMAS, K
    THIERRYMIEG, J
    SULSTON, J
    [J]. NATURE GENETICS, 1992, 1 (02) : 114 - 123
  • [49] CHARACTERIZATION OF THE EXPRESSED GENE AND SEVERAL PROCESSED PSEUDOGENES FOR THE MOUSE RIBOSOMAL-PROTEIN L30 GENE FAMILY
    WIEDEMANN, LM
    PERRY, RP
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1984, 4 (11) : 2518 - 2528
  • [50] 2.2 MB OF CONTIGUOUS NUCLEOTIDE-SEQUENCE FROM CHROMOSOME-III OF C-ELEGANS
    WILSON, R
    AINSCOUGH, R
    ANDERSON, K
    BAYNES, C
    BERKS, M
    BURTON, J
    CONNELL, M
    BONFIELD, J
    COPSEY, T
    COOPER, J
    COULSON, A
    CRAXTON, M
    DEAR, S
    DU, Z
    DURBIN, R
    FAVELLO, A
    FRASER, A
    FULTON, L
    GARDNER, A
    GREEN, P
    HAWKINS, T
    HILLIER, L
    JIER, M
    JOHNSTON, L
    JONES, M
    KERSHAW, J
    KIRSTEN, J
    LAISSTER, N
    LATREILLE, P
    LLOYD, C
    MORTIMORE, B
    OCALLAGHAN, M
    PARSONS, J
    PERCY, C
    RIFKEN, L
    ROOPRA, A
    SAUNDERS, D
    SHOWNKEEN, R
    SIMS, M
    SMALDON, N
    SMITH, A
    SMITH, M
    SONNHAMMER, E
    STADEN, R
    SULSTON, J
    THIERRYMIEG, J
    THOMAS, K
    VAUDIN, M
    VAUGHAN, K
    WATERSTON, R
    [J]. NATURE, 1994, 368 (6466) : 32 - 38