Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments

被引：280

作者：

Barghorn, S ^{[1
]}

Mandelkow, E ^{[1
]}

机构：

[1] Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany

来源：

BIOCHEMISTRY | 2002年 / 41卷 / 50期

关键词：

D O I：

10.1021/bi026469j

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease is characterized by aggregates of tau protein. Attempts to study the conditions for aggregation in vitro have led to different experimental systems, some of which appear mutually exclusive (e.g., oxidative vs reductive conditions, induction by polyanions vs fatty acids). We show here that different approaches and pathways can be viewed in a common framework, and that apparent differences can be explained by variations in the kinetics of subreactions. A unified view of PHF aggregation should help to analyze the causes of PHF aggregation and devise methods to prevent it.

引用

页码：14885 / 14896

页数：12

共 57 条

[31] IMPROVED SILVER STAINING PROCEDURE FOR FAST STAINING IN PHASTSYSTEM DEVELOPMENT UNIT .1. STAINING OF SODIUM DODECYL-SULFATE GELS
HEUKESHOVEN, J
DERNICK, R
[J]. ELECTROPHORESIS, 1988, 9 (01) : 28 - 32
[32] Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
Hutton, M
Lendon, CL
Rizzu, P
Baker, M
Froelich, S
Houlden, H
Pickering-Brown, S
Chakraverty, S
Isaacs, A
Grover, A
Hackett, J
Adamson, J
Lincoln, S
Dickson, D
Davies, P
Petersen, RC
Stevens, M
de Graaff, E
Wauters, E
van Baren, J
Hillebrand, M
Joosse, M
Kwon, JM
Nowotny, P
Che, LK
Norton, J
Morris, JC
Reed, LA
Trojanowski, J
Basun, H
Lannfelt, L
Neystat, M
Fahn, S
Dark, F
Tannenberg, T
Dodd, PR
Hayward, N
Kwok, JBJ
Schofield, PR
Andreadis, A
Snowden, J
Craufurd, D
Neary, D
Owen, F
Oostra, BA
Hardy, J
Goate, A
van Swieten, J
Mann, D
Lynch, T
[J]. NATURE, 1998, 393 (6686) : 702 - 705
[33] Jicha GA, 1997, J NEUROCHEM, V69, P2087
[34] RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments
Kampers, T
Friedhoff, P
Biernat, J
Mandelkow, EM
[J]. FEBS LETTERS, 1996, 399 (03) : 344 - 349
[35] Ligand dependent tau filament formation: Implications for Alzheimer's disease progression
King, ME
Ahuja, V
Binder, LI
Kuret, J
[J]. BIOCHEMISTRY, 1999, 38 (45) : 14851 - 14859
[36] Differential assembly of human tau isoforms in the presence of arachidonic acid
King, ME
Gamblin, TC
Kuret, J
Binder, LI
[J]. JOURNAL OF NEUROCHEMISTRY, 2000, 74 (04) : 1749 - 1757
[37] STRUCTURAL STABILITY OF PAIRED HELICAL FILAMENTS REQUIRES MICROTUBULE-BINDING DOMAINS OF TAU - A MODEL FOR SELF-ASSOCIATION
KSIEZAKREDING, H
YEN, SH
[J]. NEURON, 1991, 6 (05) : 717 - 728
[38] THE PRIMARY STRUCTURE AND HETEROGENEITY OF TAU-PROTEIN FROM MOUSE-BRAIN
LEE, G
COWAN, N
KIRSCHNER, M
[J]. SCIENCE, 1988, 239 (4837) : 285 - 288
[39] PHOSPHORYLATION-DEPENDENT EPITOPES OF NEUROFILAMENT ANTIBODIES ON TAU PROTEIN AND RELATIONSHIP WITH ALZHEIMER TAU
LICHTENBERGKRAAG, B
MANDELKOW, EM
BIERNAT, J
STEINER, B
SCHROTER, C
GUSTKE, N
MEYER, HE
MANDELKOW, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (12) : 5384 - 5388
[40] MOLECULAR CHARACTERIZATION OF THE MINIMAL PROTEASE RESISTANT TAU-UNIT OF THE ALZHEIMERS-DISEASE PAIRED HELICAL FILAMENT
NOVAK, M
KABAT, J
WISCHIK, CM
[J]. EMBO JOURNAL, 1993, 12 (01) : 365 - 370

← 1 2 3 4 5 6 →