Concentrations of CXCL8, CXCL9 and sTNFR1 in plasma of patients with pulmonary tuberculosis undergoing treatment

被引:46
作者
Alessandri, A. L.
Souza, A. L.
Oliveira, S. C.
Macedo, G. C.
Teixeira, M. M.
Teixeira, A. L.
机构
[1] Univ Fed Minas Gerais, Dept Bioquim & Imunol, Inst Ciencias Biol, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Fac Med, Dept Clin Med, BR-31270901 Belo Horizonte, MG, Brazil
关键词
pulmonary tuberculosis; chemokines; inflammation; chemotherapy of tuberculosis; cytokine; soluble TNFR;
D O I
10.1007/s00011-006-5136-9
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Background: Chemokines are a class of cytokines with chemotactic properties shown to be induced by M. tuberculosis or its antigens in vitro and in experimental infection in vivo. A few studies have also demonstrated the expression of chemokines in clinical samples of patients with active tuberculosis (TB). In the present work, we measured the concentration of chemokines in plasma samples of HIV-negative patients with pulmonary tuberculosis at different stages of chemotherapy. For comparison, we also evaluated the levels of sTNFRl and TNF-alpha. Methods: Cytokines and chemokines were measured by ELISA in healthy individuals and patients with active pulmonary TB at different stages of treatment. Results: The concentrations of CXCL8, CXCL9 and sTNFRl were elevated in patients with active pulmonary TB but returned to background levels at 4-6 months of chemotherapy. The concentration of CCL11 was elevated in patients with active pulmonary tuberculosis when compared to control and remained elevated throughout the specific therapy. There was no difference in the plasma concentration of CCL2 and CXCL10 between pulmonary TB patients and control subjects. Conclusion: Measurement of the CXCL8, CXCL9 and sTNFRl may be useful to assess response to treatment in pulmonary TB patients.
引用
收藏
页码:528 / 533
页数:6
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