Switching from life to death: The Miz-ing link between Myc and p53

被引：47

作者：

Vousden, KH ^{[1
]}

机构：

[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

来源：

CANCER CELL | 2002年 / 2卷 / 05期

关键词：

D O I：

10.1016/S1535-6108(02)00186-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cells can respond to the activation of the tumor suppressor protein p53 by undergoing cell cycle arrest or apoptosis, and Myc has now been shown to help switch the response to apoptosis by repressing the expression of p21(CIP1), a cyclin-dependent kinase inhibitor with antiapoptotic activity.

引用

页码：351 / 352

页数：2

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