An overall picture of SARS coronavirus (SARS-CoV) genome-encoded major proteins: Structures, functions and drug development

被引:13
作者
Chen, Shuai
Luo, Haibin
Chen, Lili
Chen, Jing
Shen, Jianhua
Zhu, Weiliang
Chen, Kaixian
Shen, Xu [1 ]
Jiang, Hualiang
机构
[1] Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci,Drug Discovery & Design Ct, Shanghai Inst Mat Med,State Key Lab Drug Res, Shanghai 201203, Peoples R China
[2] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
关键词
atypical pneumonia; SARS Coronavirus; SARS-CoV genome-encoded major proteins; structural and functional characterization; inhibitor design and screening; structure-based drug development;
D O I
10.2174/138161206779010459
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A severe atypical pneumonia designated as severe acute respiratory syndrome (SARS) by The World Health Organization broke out in China and menaced to more than other 30 countries between the end of the year 2002 and June of the year 2003. A novel coronavirus called severe acute respiratory syndrome coronavirus (SARS-CoV) has been recently identified as the etiological agent responsible for the infectious SARS disease. Based on extensively scientific cooperation and almost two-year's studies, remarkable achievements have been made in the understanding of the phylogenetic property and the genome organization of SARS-CoV, as well as the detailed characters of the major proteins involved in SARS-CoV life cycle. In this review, we would like to summarize the substantial scientific progress that has been made towards the structural and functional aspects of SARS-CoV associated key proteins. The progress focused oil the corresponding key proteins' structure-based drug and vaccine developments has been also highlighted. The concerted and cooperative response for the treatment of the SARS disease has been proved to be a triumph of global public health and provides a new paradigm for the detection and control of future emerging infectious disease threats.
引用
收藏
页码:4539 / 4553
页数:15
相关论文
共 106 条
[21]  
de Haan CAM, 2002, VIRUS RES, V82, P77
[22]   Coronavirus particle assembly: Primary structure requirements of the membrane protein [J].
de Haan, CAM ;
Kuo, L ;
Masters, PS ;
Vennema, H ;
Rottier, PJM .
JOURNAL OF VIROLOGY, 1998, 72 (08) :6838-6850
[23]   Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase [J].
Dhanak, D ;
Duffy, KJ ;
Johnston, VK ;
Lin-Goerke, J ;
Darey, M ;
Shaw, AN ;
Gu, BH ;
Silverman, C ;
Gates, AT ;
Nonnemacher, MR ;
Earnshaw, DL ;
Casper, DJ ;
Kaura, A ;
Baker, A ;
Greenwood, C ;
Gutshall, LL ;
Maley, D ;
DelVecchio, A ;
Macarron, R ;
Hofmann, GA ;
Alnoah, Z ;
Cheng, HY ;
Chan, G ;
Khandekar, S ;
Keenan, RM ;
Sarisky, RT .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (41) :38322-38327
[24]   The secret life of ACE2 as a receptor for the SARS virus [J].
Dimitrov, DS .
CELL, 2003, 115 (06) :652-653
[25]   EXPRESSION OF VIRUS-ENCODED PROTEINASES - FUNCTIONAL AND STRUCTURAL SIMILARITIES WITH CELLULAR ENZYMES [J].
DOUGHERTY, WG ;
SEMLER, BL .
MICROBIOLOGICAL REVIEWS, 1993, 57 (04) :781-822
[26]   The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world [J].
Egloff, MP ;
Ferron, F ;
Campanacci, V ;
Longhi, S ;
Rancurel, C ;
Dutartre, H ;
Snijder, EJ ;
Gorbalenya, AE ;
Cambillau, C ;
Canard, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (11) :3792-3796
[27]   The membrane M protein carboxy terminus binds to transmissible gastroenteritis coronavirus core and contributes to core stability [J].
Escors, D ;
Ortego, J ;
Laude, H ;
Enjuanes, L .
JOURNAL OF VIROLOGY, 2001, 75 (03) :1312-1324
[28]   Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase [J].
Fan, KQ ;
Wei, P ;
Feng, Q ;
Chen, SD ;
Huang, CK ;
Ma, L ;
Lai, B ;
Pei, JF ;
Liu, Y ;
Chen, JG ;
Lai, LH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (03) :1637-1642
[29]   Analysis of constructed E gene mutants of mouse hepatitis virus confirms a pivotal role for E protein in coronavirus assembly [J].
Fischer, F ;
Stegen, CF ;
Masters, PS ;
Samsonoff, WA .
JOURNAL OF VIROLOGY, 1998, 72 (10) :7885-7894
[30]   Prediction of proteinase cleavage sites in polyproteins of coronaviruses and its applications in analyzing SARS-CoV genomes [J].
Gao, F ;
Ou, HY ;
Chen, LL ;
Zheng, WX ;
Zhang, CT .
FEBS LETTERS, 2003, 553 (03) :451-456