Cytophilic immunoglobulin responses to Plasmodium falciparum glutamate-rich protein are correlated with protection against clinical malaria in Dielmo, Senegal

被引：127

作者：

Oeuvray, C

Theisen, M

Rogier, C

Trape, JF

Jepsen, S

Druilhe, P

机构：

[1] Inst Pasteur, Lab Parasitol Biomed, F-75015 Paris, France

[2] Statens Serum Inst, Dept Clin Biochem, DK-2300 Copenhagen, Denmark

[3] Inst Pasteur, Dakar, Senegal

[4] Inst Rech Dev, Lab Paludol, Dakar, Senegal

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 05期

关键词：

D O I：

10.1128/IAI.68.5.2617-2620.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The goal of this study was to analyze antibody responses to Plasmodium falciparum glutamate-rich protein (GLURP) using clinical data and plasma samples obtained from villagers of Dielmo, Senegal. This molecule was chosen because it is targeted by human antibodies which induce parasite growth inhibition in antibody-dependent cellular inhibition (ADCI) assays. The results showed a strong correlation between protection against malaria attacks and levels of immunoglobulin G2 (IgG2) and IgG3 against GLURP(94-489) (R0) and IgG3 against GLURP(705-1178) (R2) when corrected for the confounding effect of age-related exposure to malaria. Thus, GLURP mag play a role in the induction of protective immunity against P. falciparum malaria.

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页码：2617 / 2620

页数：4

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