Genetic regulation of host responses to Salmonella infection in mice

被引:73
作者
Roy, MF
Malo, D
机构
[1] McGill Univ, Ctr Hlth, Dept Human Genet, Montreal, PQ, Canada
[2] McGill Univ, Ctr Hlth, Dept Med, Montreal, PQ, Canada
[3] McGill Univ, Ctr Hlth, Ctr Study Host Resistance, Montreal, PQ, Canada
基金
加拿大健康研究院;
关键词
salmonella; mouse models; host response to infection; comparative genomics;
D O I
10.1038/sj.gene.6363924
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Salmonella spp are Gram-negative bacteria capable of infecting a wide range of host species, including humans, domesticated and wild mammals, reptiles, birds and insects. The outcome of an encounter between Salmonella and its host is dependent upon multiple factors including the host genetic background. To facilitate the study of the genetic factors involved in resistance to this pathogen, mouse models of Salmonella infection have been developed and studied for years, allowing identification of several genes and pathways that may influence the disease outcome. In this review, we will cover some of the genes involved in mouse resistance to Salmonella that were identified through the study of congenic mouse strains, cloning of spontaneous mouse mutations, use of site-directed mutagenesis or quantitative trait loci analysis. In parallel, the relevant information pertaining to genes involved in resistance to Salmonella in humans will be discussed.
引用
收藏
页码:381 / 393
页数:13
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