Dihydropyridines: evaluation of their current and future pharmacological applications

被引：260

作者：

Edraki, Najmeh ^{[1
]}

Mehdipour, Ahmad R. ^{[1
]}

Khoshneviszadeh, Mehdi ^{[1
]}

Miri, Ramin ^{[1
]}

机构：

[1] Shiraz Univ Med Sci, Med & Nat Prod Chem Res Ctr, Shiraz, Iran

来源：

DRUG DISCOVERY TODAY | 2009年 / 14卷 / 21-22期

关键词：

CALCIUM-CHANNEL ANTAGONIST; P-GLYCOPROTEIN INHIBITORS; MULTIDRUG-RESISTANCE; CA2+ CHANNEL; IN-VIVO; 1,4-DIHYDROPYRIDINE DERIVATIVES; GENETIC ALGORITHM; VERTEBRATE CELLS; DELIVERY-SYSTEM; BLOCKERS;

D O I：

10.1016/j.drudis.2009.08.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The 1,4-dihydropyridines (DHPs), a class of drugs, possess a wide variety of biological and pharmacological actions, have represented one of the most important groups of calcium-channel-modulating agents and have experienced widespread use in the treatment of cardiovascular disease. Moreover, it has been demonstrated that DHPs could prove to be highly important as multidrug-resistance-reversing agents in cancer chemotherapy. Recent reports suggest that this class also has other notable activities, particularly as antimycobacterial and anticonvulsant agents. Finally, it might be possible for the DHP motif to serve as a scaffold for other pharmacological applications.

引用

页码：1058 / 1066

页数：9

共 81 条

[11] Synthesis and QSAR studies of 4-substituted phenyl-2,6-dimethyl-3, 5-bis-N-(substituted phenyl)carbamoyl-1,4-dihydropyridines as potential antitubercular agents [J].

Desai, B ;

Sureja, D ;

Naliapara, Y ;

Shah, A ;

Saxena, AK .

BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (08) :1993-1998

[12] A short history of voltage-gated calcium channels [J].

Dolphin, AC .

BRITISH JOURNAL OF PHARMACOLOGY, 2006, 147 :S56-S62

[13] CHEMISTRY OF DIHYDROPYRIDINES [J].

EISNER, U ;

KUTHAN, J .

CHEMICAL REVIEWS, 1972, 72 (01) :1-+

[14] Synthesis, in vitro and in vivo evaluation of a delivery system for targeting anticancer drugs to the brain [J].

El-Sherbeny, MA ;

Al-Salem, HS ;

Sultan, MA ;

Radwan, MA ;

Farag, HA ;

El-Subbagh, HI .

ARCHIV DER PHARMAZIE, 2003, 336 (10) :445-455

[15]

FLECKENSTEIN A, 1972, ARZNEI-FORSCHUNG, V22, P22

[16]

FORD JM, 1990, PHARMACOL REV, V42, P155

[17] Design and synthesis of new symmetrical derivatives of dihydropyridine containing a pyridyl group on the 3, 5-positions and evaluation of their cytotoxic and multidrug resistance reversal activity [J].

Foroughinia, Farzaneh ;

Javidnia, Katayoun ;

Amirghofran, Zahra ;

Mehdipour, Ahmadreza ;

Miri, Ramin .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2008, 60 (11) :1481-1489

[18] THE OPTICAL ISOMERS OF THE 1,4-DIHYDROPYRIDINE BAY K-8644 SHOW OPPOSITE EFFECTS ON CA CHANNELS [J].

FRANCKOWIAK, G ;

BECHEM, M ;

SCHRAMM, M ;

THOMAS, G .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 114 (02) :223-226

[19] CARDIOVASCULAR EFFECTS OF FR34235, A NEW DIHYDROPYRIDINE SLOW CHANNEL BLOCKER, IN ISOLATED RABBIT MYOCARDIUM AND AORTA [J].

FURUTA, T ;

SHIBATA, S ;

KODAMA, I ;

YAMADA, K .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1983, 5 (05) :836-841

[20] Cancer cell permeability-glycoprotein as a target of MDR reverters: Possible role of novel dihydropyridine derivatives [J].

Fusi, F. ;

Saponara, S. ;

Valoti, M. ;

Dragoni, S. ;

D'Elia, P. ;

Sgaragli, T. ;

Alderighi, D. ;

Sgaragli, G. .

CURRENT DRUG TARGETS, 2006, 7 (08) :949-959

← 1 2 3 4 5 6 7 8 9 →