Translating metabolic exchange with imaging mass spectrometry

被引：192

作者：

Yang, Yu-Liang ^{[1
]}

Xu, Yuquan ^{[1
]}

Straight, Paul ^{[2
]}

Dorrestein, Pieter C. ^{[1
,3
,4
,5
]}

机构：

[1] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA

[2] Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA

[3] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[5] Univ Calif San Diego, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

来源：

NATURE CHEMICAL BIOLOGY | 2009年 / 5卷 / 12期

关键词：

STREPTOMYCES-COELICOLOR; BACILLUS-SUBTILIS; NONRIBOSOMAL PEPTIDES; PRODUCT; IDENTIFICATION; MEGACOMPLEX;

D O I：

10.1038/nchembio.252

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolic exchange between an organism and the environment, including interactions with neighboring organisms, is important for processes of organismal development. Here we develop and use thin-layer agar natural product MALDI-TOF imaging mass spectrometry of intact bacterial colonies grown on top of the MALDI target plate to study an interaction between two species of bacteria and provide direct evidence that Bacillus subtilis silences the defensive arsenal of Streptomyces coelicolor.

引用

页码：885 / 887

页数：3

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