Tyrosinase inhibitory and anti-tumor promoting activities of compounds isolated from safflower (Carthamus tinctorius L.) and cotton (Gossypium hirsutum L.) oil cakes

被引：36

作者：

Nagatsu, A

Zhang, HL

Mizukami, H

Okuyama, H

Sakakibara, J

Tokuda, H

Nishino, H

机构：

[1] Nagoya City Univ, Fac Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

[2] Meijo Univ, Fac Pharm, Tempaku Ku, Nagoya, Aichi 4688503, Japan

[3] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 602, Japan

来源：

NATURAL PRODUCT LETTERS | 2000年 / 14卷 / 03期

关键词：

safflower oil cake; cotton oil cake; antioxidant; tyrosinase inhibitor; anti-tumor-promoter;

D O I：

10.1080/10575630008041225

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tyrosinase inhibitory and anti-tumor promoting activities of 14 compounds isolated from safflower and cotton oil cakes were evaluated together with the two genins of glycosides, trachorogenin (8a) and quercetin (12a). Catechin(ll) and quercetin (12a) showed moderate tyrosinase inhibitory activity. N-(p-Coumaroyl)serotonin (1) and its 5-O-glucoside (3) exhibited weak anti-tyrosinase activity, but potent inhibitory activity on melanine production in the assay. Serotonin derivatives (1-4), 2-hydroxyarctiin (8), matairesinol glycoside (9) and sesquiterpene glucosides (13, 14) exhibited potent inhibitory activity on phorbol-l 2-myristate-13-acetate induced Epstein-Barr virus early antigen activation, which is the short term in vitro assay for anti-tumor-promoting activity.

引用

页码：153 / 158

页数：6

共 13 条

[11] A NEW SCREENING METHOD FOR MELANIN BIOSYNTHESIS INHIBITORS USING STREPTOMYCES-BIKINIENSIS [J].