AAA proteases in mitochondria: diverse functions of membrane-bound proteolytic machines

被引：70

作者：

Tatsuta, Takashi ^{[1
]}

Langer, Thomas ^{[1
,2
]}

机构：

[1] Univ Cologne, Inst Genet, Ctr Mol Med CMMC, Cologne Excellence Cluster Cellular Stress Respon, D-50674 Cologne, Germany

[2] Max Planck Inst Biol Aging, D-50931 Cologne, Germany

来源：

RESEARCH IN MICROBIOLOGY | 2009年 / 160卷 / 09期

基金：

欧洲研究理事会;

关键词：

AAA plus proteins; ATP-dependent proteases; Mitochondria; Mitochondrial fusion; Neurodegeneration; Quality control of proteins; HEREDITARY SPASTIC PARAPLEGIA; CHAPERONE-LIKE ACTIVITY; SACCHAROMYCES-CEREVISIAE; PROTEIN-DEGRADATION; CRISTAE MORPHOGENESIS; INTERMEMBRANE SPACE; SUBUNIT COMPOSITION; CELL-PROLIFERATION; RESPIRATORY-CHAIN; ATP HYDROLYSIS;

D O I：

10.1016/j.resmic.2009.09.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

FtsH/AAA proteases comprise a distinct family of membrane-bound, ATP-dependent proteases present in eubacteria and eukaryotic cells, where they are confined to mitochondria and chloroplasts. Here, we will summarize versatile functions of AAA proteases within mitochondria, which ensure mitochondrial integrity and cell survival, acting both as quality control and processing enzymes. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：711 / 717

页数：7

共 51 条

[1] The formation of respiratory chain complexes in mitochondria is under the proteolytic control of the m-AAA protease
Arlt, H
Steglich, G
Perryman, R
Guiard, B
Neupert, W
Langer, T
[J]. EMBO JOURNAL, 1998, 17 (16) : 4837 - 4847
[2] The YTA10-12 complex, an AAA protease with chaperone-like activity in the inner membrane of mitochondria
Arlt, H
Tauer, R
Feldmann, H
Neupert, W
Langer, T
[J]. CELL, 1996, 85 (06) : 875 - 885
[3] An Intersubunit Signaling Network Coordinates ATP Hydrolysis by m-AAA Proteases
Augustin, Steffen
Gerdes, Florian
Lee, Sukyeong
Tsai, Francis T. F.
Langer, Thomas
Tatsuta, Takashi
[J]. MOLECULAR CELL, 2009, 35 (05) : 574 - 585
[4] ATP-dependent proteases of bacteria: recognition logic and operating principles
Baker, Tania A.
Sauer, Robert T.
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 2006, 31 (12) : 647 - 653
[5] The molecular architecture of the metalloprotease FtsH
Bieniossek, C
Schalch, T
Bumann, M
Meister, M
Meier, R
Baumann, U
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (09) : 3066 - 3071
[6] CAGNOLI C, 2008, ANN M AM SOC HUM GEN
[7] Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease
Casari, G
De Fusco, M
Ciarmatori, S
Zeviani, M
Mora, M
Fernandez, P
De Michele, G
Filla, A
Cocozza, S
Marconi, R
Dürr, A
Fontaine, B
Ballabio, A
[J]. CELL, 1998, 93 (06) : 973 - 983
[8] DIBELLA D, 2008, ANN M AM SOC HUM GEN
[9] A genomewide screen for petite-negative yeast strains yields a new subunit of the i-AAA protease complex
Dunn, CD
Lee, MS
Spencer, FA
Jensen, RE
[J]. MOLECULAR BIOLOGY OF THE CELL, 2006, 17 (01) : 213 - 226
[10] Mgr3p and Mgr1p Are Adaptors for the Mitochondrial i-AAA Protease Complex
Dunn, Cory D.
Tamura, Yasushi
Sesaki, Hiromi
Jensen, Robert E.
[J]. MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (12) : 5387 - 5397

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