Hydrogels: From Soft Contact Lenses and Implants to Self-Assembled Nanomaterials

被引：289

作者：

Kopecek, Jindrich ^{[1
,2
]}

机构：

[1] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USA

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2009年 / 47卷 / 22期

基金：

美国国家卫生研究院;

关键词：

biocompatibility; drug delivery; hybrid hydrogels; hydrogels; self-assembly; self-assembly of block and graft copolymers; soft contact lenses; stimuli-responsive materials; PH-SENSITIVE HYDROGELS; GENETICALLY-ENGINEERED PROTEIN; DOUBLE-NETWORK HYDROGELS; HYDROPHILIC POLYMERS; 3-DIMENSIONAL POLYMERIZATION; 2-HYDROXYETHYL METHACRYLATE; RADICAL POLYMERIZATION; MECHANICAL-PROPERTIES; PHASE-TRANSITION; CHONDROGENIC DIFFERENTIATION;

D O I：

10.1002/pola.23607

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Hydrogels were the first biomaterials designed for clinical use. Their discovery and applications as soft contact lenses and implants are presented. This early hydrogel research served as a foundation for the expansion of biomedical polymers research into new directions: design of stimuli sensitive hydrogels that abruptly change their properties upon application of an external stimulus (pH, temperature, solvent, electrical field, biorecognition) and hydrogels as carriers for the delivery of drugs, peptides, and proteins. Finally, pathways to self-assembly of block and graft copolymers into hydrogels of precise 3D structures are introduced. (C) 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Client 47: 5929-5946, 2009

引用

页码：5929 / 5946

页数：18

共 195 条

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[62] BIODEGRADABLE HYDROGELS IN DRUG-DELIVERY [J].