TOR-driven aging Speeding car without brakes

被引：67

作者：

Blagosklonny, Mikhail V. ^{[1
]}

机构：

[1] BLSC, Roswell Pk Canc Inst, Dept Cell Stress Biol, Buffalo, NY USA

来源：

CELL CYCLE | 2009年 / 8卷 / 24期

关键词：

senescence; aging; mTOR; TOR; rapamycin; EXTENDS LIFE-SPAN; CALORIC RESTRICTION; CELLULAR SENESCENCE; C; ELEGANS; S6; KINASE; RESVERATROL; RAPAMYCIN; MTOR; INHIBITION; PATHWAY;

D O I：

10.4161/cc.8.24.10310

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This article discusses that the traditional analogy of an aging organism with a rusting (albeit self-repairing) car is misleading. The true analogy is a speeding car that enters a low-speed zone and damages itself because it does not and cannot slow down. For such a car without brakes (and actually without a driver), aging from rusting never occurs. Using simple analogies (although turning gerontology upside down), this article discusses the origin of aging, how overactivation of the mTOR (Target of Rapamycin) pathway causes aging, why aging causes damage (organ damage) not damage causes aging, the link between aging and age-related diseases, slow aging versus aging tolerance and suppression of aging with rapamycin.

引用

页码：4055 / 4059

页数：5

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