p38MAPK: stress responses from molecular mechanisms to therapeutics

被引：524

作者：

Coulthard, Lydia R. ^{[2
]}

White, Danielle E. ^{[1
]}

Jones, Dominic L. ^{[2
]}

McDermott, Michael F. ^{[2
]}

Burchill, Susan A. ^{[1
]}

机构：

[1] St James Univ Hosp, Candlelighters Childrens Canc Res Grp, LIMM, Leeds LS9 7TF, W Yorkshire, England

[2] St James Univ Hosp, NIHR Leeds Musculoskeletal Biomed Res Unit, Leeds LS9 7TF, W Yorkshire, England

来源：

TRENDS IN MOLECULAR MEDICINE | 2009年 / 15卷 / 08期

关键词：

ACTIVATED PROTEIN-KINASE; P38 MAP KINASE; NF-KAPPA-B; SPINAL MICROGLIA CONTRIBUTES; BRONCHIAL EPITHELIAL-CELLS; SIGNAL-REGULATED KINASE; TERMINAL KINASE; DIFFERENTIAL REGULATION; IL-6; PRODUCTION; NERVE LIGATION;

D O I：

10.1016/j.molmed.2009.06.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The p38(MAPK) protein kinases affect a variety of intracellular responses, with well-recognized roles in inflammation, cell-cycle regulation, cell death, development, differentiation, senescence and tumorigenesis. In this review, we examine the regulatory and effector components of this pathway, focusing on their emerging roles in biological processes involved in different pathologies. We summarize how this pathway has been exploited for the development of therapeutics and discuss the potential obstacles of targeting this promiscuous protein kinase pathway for the treatment of different diseases. Furthermore, we discuss how the p38(MAPK) pathway might be best exploited for the development of more effective therapeutics with minimal side effects in a range of specific disease settings.

引用

页码：369 / 379

页数：11

共 128 条

[91] Raf-independent deregulation of p38 and JNK mitogen-activated protein kinases are critical for Ras transformation [J].