The microRNA-17∼92 cluster Still a miRacle?

被引：111

作者：

Bonauer, Angelika ^{[1
]}

Dimmeler, Stefanie ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Cardiovasc Regenerat, Ctr Mol Med, Frankfurt, Germany

来源：

CELL CYCLE | 2009年 / 8卷 / 23期

基金：

欧洲研究理事会;

关键词：

microRNA; cancer; vascular; inflammation; cardiac; pulmonary; MIR-17-92; CLUSTER; LUNG CANCERS; N-MYC; EXPRESSION; MICRORNAS; POLYCISTRON; PROLIFERATION; ANGIOGENESIS; FIBRONECTIN; INTEGRIN;

D O I：

10.4161/cc.8.23.9994

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs (miRs) are small non-coding RNAs that regulate gene expression by binding to target mRNAs, leading to translational repression or degradation. The polycistronic microRNA cluster comprises seven mature microRNAs (miR-17-5p and -3p, miR-18a, miR-19a and b, miR-20a and miR-92a) and has initially been linked to tumorigenesis. Meanwhile, additional functions have been assigned to the cluster such as the regulation of hematopoiesis and immune functions. Recently, loss-off-function studies revealed a critically role of the miR-17 similar to 92 cluster in heart and lung development and the individual miRNAs encoded by the cluster such as miR-17 and miR-92a were shown to control lung development and postnatal neovascularization, respectively. The present article summarizes the functions of the miR-17 similar to 92 cluster in health and disease and discusses the specific contribution and the targets of the individual miRNAs encoded by the cluster.

引用

页码：3866 / 3873

页数：8

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