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Galanin overexpressing transgenic mice

被引：42
作者：
Crawley, JN
Mufson, EJ
Hohmann, JG
Teklemichael, D
Steiner, RA
Holmberg, K
Xu, ZQD
Blakeman, KH
Xu, XJ
Wiesenfeld-Hallin, Z
Bartfai, T
Hökfelt, T
机构：
[1] NIMH, Sect Behav Genom, NIH, Bethesda, MD 20892 USA
[2] Rush Presbyterian St Lukes Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA
[3] Rush Presbyterian St Lukes Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA
[4] Univ Washington, Sch Med, Dept Obstet & Gynecol, Seattle, WA 98195 USA
[5] Univ Washington, Sch Med, Dept Physiol & Biophys, Seattle, WA 98195 USA
[6] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden
[7] Huddinge Univ Hosp, Karolinska Inst, Clin Neurophysiol Sect, S-14186 Huddinge, Sweden
[8] Karolinska Inst, Dept Biochem & Biophys, S-17177 Stockholm, Sweden
[9] Scripps Res Inst, Res Inst, Dept Neuropharmacol, Harold L Dorris Neurol Res Ctr, La Jolla, CA 92037 USA
来源：
NEUROPEPTIDES | 2002年 / 36卷 / 2-3期
关键词：
D O I：
10.1054/npep.2002.0891
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Galanin overexpressing transgenic mice (GAL-tg) were generated on two different promoters. Both lines of GAL-tg displayed high levels of galanin in the hippocampus and reduced sensitivity to seizures, as compared to their respective wildtype littermate controls (WT). Performance deficits on learning and memory tasks, impaired long-term potentiation, reduced hippocampal excitability, lower evoked glutamate release, and reduced numbers of choline acetyltransferase immunoreactive neurons in the horizontal limb of the diagonal band were detected in GAL-tg as compared to WT. Changes in sensitivity to nociceptive stimuli were demonstrated in one line. GAL-tg represent a new model for investigating the biological actions of endogenous galanin, and for testing novel therapeutics based on galanin receptor ligands. (C) 2002 Elsevier Science Ltd. All rights reserved.
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收藏
页码：145 / 156
页数：12
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