Most humoral non-responders to hepatitis B vaccines develop HBV-specific cellular immune responses

被引：25

作者：

Jarrosson, L

Kolopp-Sarda, MN

Aguilar, P

Béné, MC

Lepori, ML

Vignaud, MC

Faure, GC

Kohler, C

机构：

[1] CHU, Fac Med, Immunol Lab, F-54500 Vandoeuvre Les Nancy, France

[2] CHU Nancy, F-54500 Vandoeuvre Les Nancy, France

来源：

VACCINE | 2004年 / 22卷 / 27-28期

关键词：

hepatitis B virus; humoral immunity; cellular immunity;

D O I：

10.1016/j.vaccine.2004.02.046

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

About 10% of health care professionals vaccinated against hepatitis B virus (HBV) fail to develop protective antibodies. We tested the capacity of peripheral blood lymphocytes from 121 health care professionals, including 76 non-responders, to proliferate to four HBV vaccines, examined the proliferating cells' subset, production of IFN-gamma, IL-4 and IL-10, and for 22 subjects, the cytokine production genotype. Specific proliferative responses to at least one HBV antigen were noted in 75% humoral non-responders. These cells differed from the CD4+ strongly proliferating cells of responders. Non-responders frequently displayed a genotype of high TGF-beta and intermediate IL-10 secretion. Most humoral non-responders to HBV thus develop specific cellular immune responses, eventually liable to protect them against viral infection. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：3789 / 3796

页数：8

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