Long-term treatment with interferon-β therapy for multiple sclerosis and occurrence of Graves' disease

被引:27
作者
Rotondi, M
Mazziotti, G
Biondi, B
Manganella, G
Del Buono, A
Montella, P
di Cristofaro, M
Di Lorio, G
Amato, G
Carella, C
机构
[1] Univ Naples Federico II, Ist Endocrinol, Naples, Italy
[2] Univ Naples Federico II, Ist Neurol, Naples, Italy
[3] Univ Naples Federico II, Ist Endocrinol, Naples, Italy
关键词
thyroid autoimmunity; Graves; hyperthyroidism; TRAb; multiple sclerosis; IFN-beta; cytokines;
D O I
10.1007/BF03343730
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Interferon (IFN)-beta has become a widespread therapy for multiple sclerosis. As already reported for IFN-alpha, thyroid autoimmunity and dysfunctions have been observed also in course of IFN-beta therapy. Nevertheless, very few cases of Graves' disease, occurred in such condition, have been reported in literature. We here describe the case of a 40-year-old female affected by multiple sclerosis, who received IFN-beta-1b, 8 million IU sc every other day for her condition. After 22 months of cytokine administration, she developed a severe Graves' disease with persistently positive TRAb which suggested the withdrawal of the treatment. Our patient had performed a complete thyroid evaluation with normal findings, before and during the first 6 months of therapy. This case suggests that patients undergoing long-term IFN-beta therapy should be monitored for thyroid hormones and antibodies throughout the treatment as thyroidal side effect can be a late event. (C) 2000. Editrice Kurtis.
引用
收藏
页码:321 / 324
页数:4
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