Palladium catalyzed addition of carbon pronucleophiles to conjugated enynes

被引:21
作者
Gevorgyan, V
Kadowaki, C
Salter, MM
Kadota, I
Saito, S
Yamamoto, Y
机构
[1] TOHOKU UNIV,GRAD SCH SCI,DEPT CHEM,SENDAI,MIYAGI 98077,JAPAN
[2] TOHOKU UNIV,INST CHEM REACT SCI,RES CTR ORGAN RESOURCES & MAT CHEM,SENDAI,MIYAGI 98077,JAPAN
关键词
D O I
10.1016/S0040-4020(97)00602-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Palladium catalyzed addition of certain carbon pronucleophiles 2 to conjugated enynes 1 afforded the corresponding allenes 3 in good to excellent yields. The most reactive methynes such as methylmalononitrile 2c enabled to undergo double addition leading to alkenes 4. Catalyst optimization supported Pd-2(dba)(3) . CHC3 - dppf combination as the best system among all catalysts tested. The plausible mechanisms for these catalytic reactions were proposed. (C) 1997 Elsevier Science Ltd.
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页码:9097 / 9106
页数:10
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