Hybrids of macrolides and nucleobases or nucleosides

被引：8

作者：

Costa, AM ^{[1
]}

Vilarrasa, J ^{[1
]}

机构：

[1] Univ Barcelona, Fac Quim, Dept Quim Organ, E-08028 Barcelona, Catalonia, Spain

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 18期

关键词：

antibiotics; macrolides; uracils; uridines;

D O I：

10.1016/S0040-4039(00)00417-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A few examples of hybrids/conjugates/chimeras of erythromycin A derivatives and nucleobases (uracil and thymine) or thymidine-derived nucleosides are reported. Linkers and reaction conditions have been investigated to avoid the degradation of the macrolide moiety (glycoside hydrolysis, ring cleavage, dehydration, etc.). (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：3371 / 3375

页数：5

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