Vitamin D and cancer

被引:160
作者
Bouillon, Roger [1 ]
Eelen, Guy [1 ]
Verlinden, Lieve [1 ]
Mathieu, Chantal [1 ]
Carmeliet, Geert [1 ]
Verstuyf, Annemieke [1 ]
机构
[1] Lab Expt Med & Endocrinol, B-3000 Louvain, Belgium
关键词
D O I
10.1016/j.jsbmb.2006.09.014
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
1,25-dihydroxy Vitamin D [1,25-(OH)2D] exerts its effects via the vitamin D receptor (VDR) that belongs to the steroid/thyroid hormone receptor superfamily leading to gene regulation which results in various biological responses. Within the last two decades, the receptor has been shown to be present not only in classical target tissues such as bone, kidney and intestine but also in many other non-classical tissues. Besides the almost universal presence of VDRs, some cell types (e.g. keratinocytes, monocytes, bone, placenta) are capable of metabolizing 25-hydroxyvitamin D to 1,25(OH)2D by the enzyme 1α-hydroxylase (CYP27B1). The combined presence of 25(OH)D-1α-hydroxylase as well as the specific receptor in several tissues introduced the idea of a paracrine role for 1,25(OH)2D. Moreover, it has been demonstrated that 1,25(OH)2D can induce differentiation and inhibit proliferation of a wide variety of cell types. The molecular mechanisms behind this antiproliferative action is thoroughly explored but the whole picture is still difficult to understand. Important cell cycle regulators are involved such as cyclins, cyclin dependent kinases and their corresponding inhibitors as well as E2F transcription factors and accompanying pocket proteins. However the precise hierarchical structure of this wide diversity of actions of 1,25(OH)2D on genes influencing cell cycle progression is not firmly established nor do we understand which pathways are essential and which redundant. The antiproliferative action makes 1,25-(OH)2D and its analogs a possible therapeutic tool to treat hyperproliferative disorders, among which different types of cancer. This review focuses on the effects of 1,25(OH)2D and its analogs on cell proliferation, the results in in vivo experiments in Vitamin D deficient or resistant animals to cancer and the current epidemiological and intervention studies linking Vitamin D status or treatment and human cancer. © 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:156 / 162
页数:7
相关论文
共 55 条
[41]  
Solomon C, 2001, RADIAT RES, V155, P156, DOI 10.1667/0033-7587(2001)155[0156:VDRIRT]2.0.CO
[42]  
2
[43]   Convergence of vitamin D and retinoic acid signalling at a common hormone response element [J].
Tavera-Mendoza, L ;
Wang, TT ;
Lallemant, B ;
Zhang, R ;
Nagai, Y ;
Bourdeau, R ;
Calderon, MR ;
Desbarats, J ;
Mader, S ;
White, JH .
EMBO REPORTS, 2006, 7 (02) :180-185
[44]   Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: A longitudinal, nested case-control study in the Nordic countries [J].
Tuohimaa, P ;
Tenkanen, L ;
Ahonen, M ;
Lumme, S ;
Jellum, E ;
Hallmans, G ;
Stattin, P ;
Harvei, S ;
Hakulinen, T ;
Luostarinen, T ;
Dillner, J ;
Lehtinen, M ;
Hakama, M .
INTERNATIONAL JOURNAL OF CANCER, 2004, 108 (01) :104-108
[45]   Duodenal calcium absorption in vitamin D receptor-knockout mice: Functional and molecular aspects [J].
Van Cromphaut, SJ ;
Dewerchin, M ;
Hoenderop, JGJ ;
Stockmans, I ;
Van Herck, E ;
Kato, S ;
Bindels, RJM ;
Collen, D ;
Carmeliet, P ;
Bouillon, R ;
Carmeliet, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (23) :13324-13329
[46]   SERUM VITAMIN-D CONCENTRATIONS AMONG ELDERLY PEOPLE IN EUROPE [J].
VANDERWIELEN, RPJ ;
LOWIK, MRH ;
VANDENBERG, H ;
DEGROOT, LCPGM ;
HALLER, J ;
MOREIRAS, O ;
VANSTAVEREN, WA .
LANCET, 1995, 346 (8969) :207-210
[47]  
Vegesna V, 2003, ANTICANCER RES, V23, P283
[48]   Characterization of the condensin component Cnap1 and protein kinase Melk as novel E2F target genes down-regulated by 1,25-dihydroxyvitamin D3 [J].
Verlinden, L ;
Eelen, G ;
Beullens, I ;
Van Camp, M ;
Van Hummelen, P ;
Engelen, K ;
Van Hellemont, R ;
Marchal, K ;
De Moor, B ;
Foijer, F ;
Riele, HT ;
Beullens, M ;
Bollen, M ;
Mathieu, C ;
Bouillon, R ;
Verstuyf, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (45) :37319-37330
[49]  
Verlinden L, 2000, CANCER RES, V60, P2673
[50]   Calcium plus vitamin D supplementation and the risk of colorectal cancer [J].
Wactawski-Wende, J ;
Kotchen, JM ;
Anderson, GL ;
Assaf, AR ;
Brunner, RL ;
O'Sullivan, MJ ;
Margolis, KL ;
Ockene, JK ;
Phillips, L ;
Pottern, L ;
Prentice, RL ;
Robbins, J ;
Rohan, TE ;
Sarto, GE ;
Sharma, S ;
Stefanick, ML ;
Van Horn, L ;
Wallace, RB ;
Whitlock, E ;
Bassford, T ;
Beresford, SAA ;
Black, HR ;
Bonds, DE ;
Brzyski, RG ;
Caan, B ;
Chlebowski, RT ;
Cochrane, B ;
Garland, C ;
Gass, M ;
Hays, J ;
Heiss, G ;
Hendrix, SL ;
Howard, BV ;
Hsia, J ;
Hubbell, FA ;
Jackson, RD ;
Johnson, KC ;
Judd, H ;
Kooperberg, CL ;
Kuller, LH ;
LaCroix, AZ ;
Lane, DS ;
Langer, RD ;
Lasser, NL ;
Lewis, CE ;
Limacher, MC ;
Manson, JE .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (07) :684-696