Lipopeptides from Staphylococcus aureus as Tlr2 Ligands: Prediction with mRNA Expression, Chemical Synthesis, and Immunostimulatory Activities

被引：15

作者：

Fujimoto, Yukari ^{[1
]}

Hashimoto, Masahito ^{[2
]}

Furuyashiki, Maiko ^{[2
]}

Katsumoto, Mami ^{[1
]}

Seya, Tsukasa ^{[4
]}

Suda, Yasuo ^{[2
,3
]}

Fukase, Koichi ^{[1
]}

机构：

[1] Osaka Univ, Dept Chem, Grad Sch Sci, Osaka 5600043, Japan

[2] Kagoshima Univ, Dept Nanostruct & Adv Mat, Kagoshima 8900065, Japan

[3] Hokkaido Univ, Grad Sch Med, Dept Microbiol & Immunol, Sapporo, Hokkaido 0608638, Japan

[4] Kagoshima Univ, Venture Business Lab, Kagoshima 8900065, Japan

来源：

CHEMBIOCHEM | 2009年 / 10卷 / 14期

基金：

日本学术振兴会;

关键词：

immunology; lipoproteins; Staphylococcus aureus; Toll-like receptor 2; HUMAN GINGIVAL FIBROBLASTS; ESCHERICHIA-COLI; BACTERIAL PROLIPOPROTEIN; MYCOPLASMA-SALIVARIUM; MUREIN-LIPOPROTEIN; LIPOTEICHOIC ACID; OUTER MEMBRANE; CELL-WALL; DERIVATIVES; FERMENTANS;

D O I：

10.1002/cbic.200900242

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(Chemical Equation Presented) Recognize this? Based on predictions from mRNA expression of lipoproteins from Staphylococcus aureus, lipopeptide fragments were chemically synthesized, and their TLR2-stimulatory activities and cytokine-induction capabilities were analyzed. All the lipopeptides activated TLR2, but the activities varied depending on their peptide sequences. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2311 / 2315

页数：5

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