Free radicals and antioxidants in cardiovascular disease

被引:127
作者
Maxwell, SRJ
Lip, GYH
机构
[1] UNIV BIRMINGHAM, CITY HOSP, DEPT MED, HAEMOSTASIS THROMBOSIS & VASC BIOL UNIT, BIRMINGHAM B18 7QH, W MIDLANDS, ENGLAND
[2] LEICESTER ROYAL INFIRM, DEPT CLIN PHARMACOL, LEICESTER, LEICS, ENGLAND
关键词
antioxidants; coronary artery disease; free radicals; vitamin E;
D O I
10.1046/j.1365-2125.1997.t01-1-00594.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Several lines of evidence suggest that free radical-mediated oxidative damage to lipoproteins may be an important factor predisposing them to uptake into the vascular wall. This has led to interest in the factors that determine the susceptibility of lipoproteins to oxidation and their relationship to the development of coronary heart disease. Of these factors, the lipoprotein content of natural antioxidant vitamins such as vitamin E, and beta-carotene have aroused particular interest. Studies in animal models of atherosclerosis suggest that natural and synthetic antioxidants can retard the development of atheroma. Epidemiological comparisons between populations and studies within populations also support the contention that high plasma levels or dietary intake of natural antioxidant vitamins may protect against the development of coronary disease in man. Prospective randomized controlled trials of antioxidants in high risk groups are underway to test whether the theoretical promise of a beneficial role for antioxidants in coronary heart disease prevention will be fufilled.
引用
收藏
页码:307 / 317
页数:11
相关论文
共 69 条
[41]   DIRECT OBSERVATION OF A FREE-RADICAL INTERACTION BETWEEN VITAMIN-E AND VITAMIN-C [J].
PACKER, JE ;
SLATER, TF ;
WILLSON, RL .
NATURE, 1979, 278 (5706) :737-738
[42]   LOW-DENSITY LIPOPROTEIN UNDERGOES OXIDATIVE MODIFICATION INVIVO [J].
PALINSKI, W ;
ROSENFELD, ME ;
YLAHERTTUALA, S ;
GURTNER, GC ;
SOCHER, SS ;
BUTLER, SW ;
PARTHASARATHY, S ;
CAREW, TE ;
STEINBERG, D ;
WITZTUM, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (04) :1372-1376
[43]   LOW-DENSITY-LIPOPROTEIN RICH IN OLEIC-ACID IS PROTECTED AGAINST OXIDATIVE MODIFICATION - IMPLICATIONS FOR DIETARY PREVENTION OF ATHEROSCLEROSIS [J].
PARTHASARATHY, S ;
KHOO, JC ;
MILLER, E ;
BARNETT, J ;
WITZTUM, JL ;
STEINBERG, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (10) :3894-3898
[44]   OXIDATIVELY MODIFIED LOW-DENSITY LIPOPROTEINS - A POTENTIAL ROLE IN RECRUITMENT AND RETENTION OF MONOCYTE MACROPHAGES DURING ATHEROGENESIS [J].
QUINN, MT ;
PARTHASARATHY, S ;
FONG, LG ;
STEINBERG, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (09) :2995-2998
[45]   LEUKOCYTE ASCORBIC-ACID AND ITS RELATIONSHIP TO CORONARY-ARTERY DISEASE IN MAN [J].
RAMIREZ, J ;
FLOWERS, NC .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1980, 33 (10) :2079-2087
[46]   EFFECTS OF OLEATE-RICH AND LINOLEATE-RICH DIETS ON THE SUSCEPTIBILITY OF LOW-DENSITY-LIPOPROTEIN TO OXIDATIVE MODIFICATION IN MILDLY HYPERCHOLESTEROLEMIC SUBJECTS [J].
REAVEN, P ;
PARTHASARATHY, S ;
GRASSE, BJ ;
MILLER, E ;
STEINBERG, D ;
WITZTUM, JL .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (02) :668-676
[47]   EFFECT OF DIETARY ANTIOXIDANT COMBINATIONS IN HUMANS - PROTECTION OF LDL BY VITAMIN-E BUT NOT BY BETA-CAROTENE [J].
REAVEN, PD ;
KHOUW, A ;
BELTZ, WF ;
PARTHASARATHY, S ;
WITZTUM, JL .
ARTERIOSCLEROSIS AND THROMBOSIS, 1993, 13 (04) :590-600
[48]   EFFECT OF PROBUCOL TREATMENT ON THE SUSCEPTIBILITY OF LOW-DENSITY-LIPOPROTEIN ISOLATED FROM HYPERCHOLESTEROLEMIC PATIENTS TO BECOME OXIDATIVELY MODIFIED INVITRO [J].
REGNSTROM, J ;
WALLDIUS, G ;
CARLSON, LA ;
NILSSON, J .
ATHEROSCLEROSIS, 1990, 82 (1-2) :43-51
[49]   RISK OF ANGINA-PECTORIS AND PLASMA-CONCENTRATIONS OF VITAMIN-A, VITAMIN-C, AND VITAMIN-E AND CAROTENE [J].
RIEMERSMA, RA ;
WOOD, DA ;
MACINTYRE, CCA ;
ELTON, RA ;
GEY, KF ;
OLIVER, MF .
LANCET, 1991, 337 (8732) :1-5
[50]  
RIEMERSMA RA, 1990, EUR J CLIN NUTR, V44, P143