One-pot tandem enantioselective hydrogenation- hydroformylation synthesis of cyclic α-amino acids

被引：21

作者：

Teoh, E

Campi, EM

Jackson, WR

Robinson, AJ

机构：

[1] Monash Univ, Ctr Green Chem, Clayton, Vic 3800, Australia

[2] Monash Univ, Sch Chem, Clayton, Vic 3800, Australia

来源：

NEW JOURNAL OF CHEMISTRY | 2003年 / 27卷 / 02期

关键词：

D O I：

10.1039/b209087m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Five- and six-membered cyclic amino acids can be prepared in good yield with high ee ( > 95%) via tandem rhodium-DuPHOS catalysed asymmetric hydrogenation followed by a rhodium-catalysed hydroformylation cyclisation sequence in a single pot. The synthesis can be achieved using Rh-DuPHOS as the sole catalyst.

引用

页码：387 / 394

页数：8

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