Effect of Surface Properties on Nanoparticle-Cell Interactions

被引：2160

作者：

Verma, Ayush ^{[1
]}

Stellacci, Francesco ^{[1
]}

机构：

[1] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA

来源：

SMALL | 2010年 / 6卷 / 01期

关键词：

cell penetration; drug delivery; nanobiotechnology; nanomateriats; nanoparticles; SUPPORTED LIPID-BILAYERS; QUANTUM-DOT NANOPARTICLES; GOLD NANOPARTICLES; PENETRATING PEPTIDES; INTRACELLULAR DELIVERY; POLYCATIONIC POLYMERS; OXIDE NANOPARTICLES; FE3O4; NANOPARTICLES; PROTEIN ADSORPTION; CYTOSOLIC DELIVERY;

D O I：

10.1002/smll.200901158

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The interaction of nanomaterials with cells and lipid bilayers is critical in many applications such as phototherapy, imaging, and drug/gene delivery. These applications require a firm control over nanoparticle-cell interactions, which are mainly dictated by surface properties of nanoparticles. This critical Review presents an understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells. Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：12 / 21

页数：10

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