Planarian Hh Signaling Regulates Regeneration Polarity and Links Hh Pathway Evolution to Cilia

被引:180
作者
Rink, Jochen C. [1 ]
Gurley, Kyle A. [1 ]
Elliott, Sarah A. [1 ]
Alvarado, Alejandro Sanchez [1 ]
机构
[1] Univ Utah, Howard Hughes Med Inst, Dept Neurobiol & Anat, Sch Med, Salt Lake City, UT 84103 USA
关键词
ZINC-FINGER PROTEIN; SONIC HEDGEHOG; ZEBRAFISH EMBRYO; STEM-CELLS; GENE; DROSOPHILA; HOMOLOG; MOUSE; CONSERVATION; MICE;
D O I
10.1126/science.1178712
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The Hedgehog (Hh) signaling pathway plays multiple essential roles during metazoan development, homeostasis, and disease. Although core protein components are highly conserved, the variations in Hh signal transduction mechanisms exhibited by existing model systems ( Drosophila, fish, and mammals) are difficult to understand. We characterized the Hh pathway in planarians. Hh signaling is essential for establishing the anterior/posterior axis during regeneration by modulating wnt expression. Moreover, RNA interference methods to reduce signal transduction proteins Cos2/Kif27/Kif7, Fused, or Iguana do not result in detectable Hh signaling defects; however, these proteins are essential for planarian ciliogenesis. Our study expands the understanding of Hh signaling in the animal kingdom and suggests an ancestral mechanistic link between Hh signaling and the function of cilia.
引用
收藏
页码:1406 / 1410
页数:5
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