Stimuli-responsive amphiphilic (co)polymers via RAFT polymerization

被引：361

作者：

Smith, Adam E. ^{[1
]}

Xu, Xuewei ^{[1
]}

McCormick, Charles L. ^{[1
,2
]}

机构：

[1] Univ So Mississippi, Dept Polymer Sci, Hattiesburg, MS 39406 USA

[2] Univ So Mississippi, Dept Chem & Biochem, Hattiesburg, MS 39406 USA

来源：

PROGRESS IN POLYMER SCIENCE | 2010年 / 35卷 / 1-2期

基金：

美国国家科学基金会;

关键词：

Reversible addition-fragmentation chain transfer polymerization; RAFT; Controlled radical polymerization; Stimuli-responsive block copolymers; Shell cross-linking; Water soluble polymers; ADDITION-FRAGMENTATION CHAIN; CROSS-LINKED MICELLES; LIVING RADICAL POLYMERIZATION; THERMORESPONSIVE BLOCK-COPOLYMERS; AQUEOUS-SOLUTION PROPERTIES; WATER-SOLUBLE POLYMERS; HYDROPHILIC DIBLOCK COPOLYMER; MULTIWALLED CARBON NANOTUBES; HEAT-INDUCED ASSOCIATION; BAB TRIBLOCK COPOLYMERS;

D O I：

10.1016/j.progpolymsci.2009.11.005

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Over the last decade reversible addition-fragmentation chain transfer (RAFT) polymerization has become a powerful technique for the preparation of well-defined copolymer architectures. Specifically, water-soluble, stimuli-responsive block, graft, and Star copolymers have become especially significant in targeted delivery of diagnostic and therapeutic agents. In many cases RAFT polymerization is carried out directly in water at ambient temperature without the need for protecting group chemistry. Incorporation of functional monomers and selection of appropriate chain transfer agents (CTAs) allows facile, post-polymerization transformations of structopendant or structoterminal groups. This review focuses specifically on advances in the synthesis of (co)polymers from water-soluble monomers yielding stimuli-responsive systems. Additionally, we focus on recent reports of assembly into micelles and polymersomes induced by external stimuli including temperature, pH, and ionic strength. Reversible cross-linking methods to "lock" such assembled morphologies are addressed as well as potential applications in nanomedicine. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：45 / 93

页数：49

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