Direct Alkenylation and Alkylation of Pyridone Derivatives by Ni/AlMe3 Catalysis

被引：208

作者：

Nakao, Yoshiaki ^{[1
]}

Idei, Hiroaki ^{[1
]}

Kanyiva, Kyalo Stephen ^{[1
]}

Hiyama, Tamejiro ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Kyoto 6158510, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 44期

关键词：

NICKEL/LEWIS-ACID CATALYSIS; PYRIMIDINE; ALKYNES;

D O I：

10.1021/ja907214t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Regioselective alkenylation and alkylation of 2-pyridone derivatives are achieved through inter- and intramolecular insertion of alkynes, 1,3-dienes, and alkenes into the C(6)-H bond by nickel/AlMe3 catalysis. Coordination of the heterocycles to the Lewis acid cocatalyst through their basic carbonyl oxygen is considered to be responsible for the regioselective activation of the C-H bonds, probably through oxidative addition to nickel(0).

引用

页码：15996 / +

页数：3

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