Conformational control of transmembrane Cl- transport

被引：131

作者：

Santacroce, Paul V.

Davis, Jeffery T. ^{[1
]}

Light, Mark E.

Gale, Philip A.

Iglesias-Sanchez, Jose Carlos

Prados, Pilar

Quesada, Roberto

机构：

[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

[2] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

[3] Univ Autonoma Madrid, Dept Quim Organ, E-28049 Madrid, Spain

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 07期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/ja068067v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Preorganization of the isophthalamide cleft in N,N'-dibutyl-4,6-dihydroxyisophthalamide (2) by means of intramolecular hydrogen bonds results in an enhanced anion receptor that displays significant chloride transport activity into EYPC liposomes. This function is easily switchable by controlling the pH.

引用

收藏

页码：1886 / +

页数：3

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共 26 条

[11] Simple naphthalimide based anion sensors:: deprotonation induced colour changes and CO2 fixation [J].

Gunnlaugsson, T ;

Kruger, PE ;

Jensen, P ;

Pfeffer, FM ;

Hussey, GM .

TETRAHEDRON LETTERS, 2003, 44 (49) :8909-8913

[12] Multiple hydrogen bond stabilization of a sandwich complex of sulfate between two macrocyclic tetraamides [J].

Hossain, MA ;

Llinares, JM ;

Powell, D ;

Bowman-James, K .

INORGANIC CHEMISTRY, 2001, 40 (13) :2936-2937

[13] Enhanced carboxylate binding using urea and amide-based receptors with internal Lewis acid coordination: A cooperative polarization effect [J].

Hughes, MP ;

Smith, BD .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (13) :4492-4499

[14] A BINARY QUINONE RECEPTOR [J].

HUNTER, CA ;

PURVIS, DH .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1992, 31 (06) :792-795

[15] EQNMR - A COMPUTER-PROGRAM FOR THE CALCULATION OF STABILITY-CONSTANTS FROM NUCLEAR-MAGNETIC-RESONANCE CHEMICAL-SHIFT DATA [J].

HYNES, MJ .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1993, (02) :311-312

[16] Attenuation of Hofmeister bias in ion-pair extraction by a disulfonamide anion host used in strikingly effective synergistic combination with a calix-crown Cs+ host [J].

Kavallieratos, K ;

Moyer, BA .

CHEMICAL COMMUNICATIONS, 2001, (17) :1620-1621

[17] Hydrogen bonding in anion recognition: A family of versatile, nonpreorganized neutral and acyclic receptors [J].

Kavallieratos, K ;

Bertao, CM ;

Crabtree, RH .

JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (05) :1675-1683

[18] A readily available non-preorganized neutral acyclic halide receptor with an unusual nonplanar binding conformation [J].

Kavallieratos, K ;

deGala, SR ;

Austin, DJ ;

Crabtree, RH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (09) :2325-2326

[19] Anion recognition by 1,3-benzenedisulfonamide derivatives bearing phenolic hydroxy groups in MeCN-d3 [J].

Kondo, S ;

Suzuki, T ;

Toyama, T ;

Yano, Y .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2005, 78 (07) :1348-1350

[20] A fluorescent assay for chloride transport; identification of a synthetic anionophore with improved activity [J].

McNally, BA ;

Koulov, AV ;

Smith, BD ;

Joos, JB ;

Davis, AP .

CHEMICAL COMMUNICATIONS, 2005, (08) :1087-1089